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Efficacy and Safety of Cilostazol in Mild Cognitive Impairment: A Randomized Clinical Trial.
JAMA Netw Open
December 2023
Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
Importance: Recent evidence indicates the efficacy of β-amyloid immunotherapy for the treatment of Alzheimer disease, highlighting the need to promote β-amyloid removal from the brain. Cilostazol, a selective type 3 phosphodiesterase inhibitor, promotes such clearance by facilitating intramural periarterial drainage.
Objective: To determine the safety and efficacy of cilostazol in mild cognitive impairment.
Antibodies against native proteins of Mycobacterium tuberculosis can detect pulmonary tuberculosis patients.
Sci Rep
August 2023
Department of Bacteriology, School of Medicine, Niigata University, Asahimachi-Dori 1-757, Chuo-ku, Niigata, 951-8510, Japan.
Accurate point-of-care testing (POCT) is critical for managing tuberculosis (TB). However, current antibody-based diagnosis shows low specificity and sensitivity. To find proper antigen candidates for TB diagnosis by antibodies, we assessed IgGs responsiveness to Mycobacterium tuberculosis proteins in pulmonary TB (PTB) patients.
View Article and Find Full Text PDFPhelliribsin B: A New Styrylpyrone Derivative from the Medicinal Fungus Phellinus ribis.
Chem Biodivers
November 2022
School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355, P. R. China.
A novel styrylpyrone derivative, named phelliribsin B (1), as well as four biogenetically related known compounds, phellifuropyranone A (2), inoscavin C (3), inoscavin A (4), and inoscavin D (5) were separated and purified from the medicinal fungus Phellinus ribis. The structure of phelliribsin B was determined by spectroscopic analysis, and the absolute configuration was assigned by experimental and calculated ECD data. Additionally, the plausible biosynthetic pathway of 1 was also proposed.
View Article and Find Full Text PDFIntramedullary nailing of lateral malleolus in ankle fractures - surgical technique and literature review.
Rev Col Bras Cir
June 2020
Universidade Federal do Rio de Janeiro (UFRJ), Departamento de Radiologia - Rio de Janeiro - RJ - Brasil.
Our objective is to describe the technique of intramedullary (IM) nailing of lateral malleolus in the surgical management of ankle fractures. Fracture reduction is performed either percutaneously with a small pointed reduction clamp in simple oblique fractures or using longitudinal traction and rotation for comminuted fractures, thus reducing complications related to open reduction and internal fixation with a plate. The technique has been shown to be simple and reproducible.
View Article and Find Full Text PDFNailing the fibula: alternative or standard treatment for lateral malleolar fracture fixation? A broken paradigm.
Eur J Trauma Emerg Surg
December 2021
Academic Department of Trauma and Orthopaedic Surgery, School of Medicine, University of Leeds, Leeds, UK.
Purpose: Despite the fact that open reduction and internal fixation with a plate, either non-locked or locked, is the standard of care for managing lateral malleolus fractures, intramedullary (IM) fixation of the fibula has been recently introduced as an alternative, mainly for some potential complicated situations. We hypothesized that almost all patterns of distal fibula fracture can be safely fixed with an IM device, with the potential benefit of providing biomechanical efficiency, but using a soft-tissue friendly implant. Here, we present a multicenter case series based on a proposed algorithm.
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