Introduction: Overweight and obesity in in young people especially in children and adolescents is considered as public health problem in the world. Obesity could be the most important cause of insulin resistance. For this reason obese children and adolescents become in a risky group for developing metabolic syndrome (MS). In Ecuador is shocking the low following that is given to the diagnosis of MS for predicting the risk of cardio and cerebral vascular disease and diabetes mellitus.
Objective: To determine the prevalence of metabolic syndrome and its risk factors in a sample of students from the "Universidad Central del Ecuador" (UCE) in Quito.
Methods: Students form first, second and third semester of Medicine College in UCE were included in the study. The age range was between 17 and 25 years old. All students were measured weight, height, body mass index (BMI, blood pressure, waist circumference and serum levels of total cholesterol, HDL, LDL, triglycerides and glucose.
Results: The study shows that the prevalence of MS was 7.58% (IDF). It means that 1 of 13 students had MS. 22.24% has pre obesity and 3.14% has obesity. We found that waist circumference was mainly higher in women than men (33.67% vs. 9.55) of the 31.79% of low values of HDLc, the 24.50% occurred among women and 7.29% among men. , the values of total cholesterol, LDL cholesterol and glucose were normal.
Conclusion: In the tested sample was found that 1 out of 13 students had MS and 1 out of 2 had at least one risk factor for MS. According with the pre-obesity and obesity result, 1 out of 4 students shows one of these symptoms. In addition, these results show the direct relationship between risk factors and TA. Finally, Healthy lifestyles promotion (includes non-pharmacological treatments such diet and exercise) could be the first goal to prevent metabolic disease, because the large amount of persons with at least one risk factor for MS.
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http://dx.doi.org/10.3305/nh.2015.31.4.8371 | DOI Listing |
Elife
January 2025
The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, United Kingdom.
encodes three regulatory subunits of class IA phosphoinositide 3-kinase (PI3K), each associating with any of three catalytic subunits, namely p110α, p110β, or p110δ. Constitutional mutations cause diseases with a genotype-phenotype relationship not yet fully explained: heterozygous loss-of-function mutations cause SHORT syndrome, featuring insulin resistance and short stature attributed to reduced p110α function, while heterozygous activating mutations cause immunodeficiency, attributed to p110δ activation and known as APDS2. Surprisingly, APDS2 patients do not show features of p110α hyperactivation, but do commonly have SHORT syndrome-like features, suggesting p110α hypofunction.
View Article and Find Full Text PDFActa Obstet Gynecol Scand
January 2025
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Introduction: Recurrent pregnancy loss (RPL), defined as two or more consecutive pregnancy losses before 24 weeks of gestation, affects up to 1%-2% of couples. Aim of this retrospective cohort study was to report the main causes and pregnancy outcomes of a cohort of women with RPL and the efficacy of a personalized work-up and treatment in terms of live birth rate.
Material And Methods: Women with primary (pRPL) and secondary (sRPL) RPL underwent a complete work-up and personalized therapeutic management.
Front Endocrinol (Lausanne)
January 2025
Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari Aldo Moro, Bari, Italy.
Indian J Clin Biochem
January 2025
Department of Biochemistry, Velammal Medical College Hospital and Research Institute, Madurai, Tamil Nadu 632002 India.
Unlabelled: Non-alcoholic fatty liver disease (NAFLD) is one of the major causes of chronic liver disease worldwide. There are conflicting reports on the association of serum ferritin levels and its utility in discriminating various stages of liver fibrosis in patients with NAFLD. This study is done to address the conflicts by analysing the National Health and Nutritional Examination Survey 2017-2020 (NHANES 2017-2020) data.
View Article and Find Full Text PDFMol Genet Metab Rep
March 2025
Department of Biochemistry, JSS Medical College and Hospital, JSS-AHER, Mysuru 570015, India.
Mitochondrial DNA (mtDNA) variants considerably affect diabetes mellitus by disturbing mitochondrial function, energy metabolism, oxidative stress response, and even insulin secretion. The m.3243 A > G variants is associated with maternally inherited diabetes and deafness (MIDD), where early onset diabetes and hearing loss are prominent features.
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