Dynamic kinetic resolutions have proven to be a useful method for the preparation of enantiopure compounds from racemates, leading to the formation of a single enantiomer in theoretically 100% yield. Because lipases are ubiquitous, versatile, stereoselective and robust biocatalysts, they have been successfully applied as co-catalysts in these reactions, being mostly combined with metals in the chemoenzymatic dynamic kinetic resolutions of alcohols and amines.
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http://dx.doi.org/10.1016/j.biotechadv.2015.02.015 | DOI Listing |
J Pharm Sci
December 2024
SSPC Centre for Pharmaceutical Research, School of Pharmacy, University College Cork, Cork, T12 YT20, Ireland. Electronic address:
With the increasing development of oral peptide dosage forms, a comprehensive understanding of factors affecting peptide drug stability in the solid-state is critical. This study used human insulin, as a model peptide, to examine the individual and interactive effects of temperature and humidity on its solid-state stability. Insulin was stored at temperature (25°C, 40°C, and 6 °C) and humidity (1%, 33% and 75%) over 6 months.
View Article and Find Full Text PDFACS Nano
December 2024
Department of Chemistry, University of California, Berkeley, California 94720, United States.
Characterizing the size, structure, and composition of nanoparticles is vital in predicting and understanding their macroscopic properties. In this work, charge detection mass spectrometry (CDMS) was used to analyze nanocapsules (∼10-200 MDa) consisting of a liquid oleic acid core surrounded by a dense silica outer shell. CDMS is an emerging method for nanoparticle analysis that can rapidly measure the mass and charge of thousands of individual nanoparticles.
View Article and Find Full Text PDFJ Phys Chem B
December 2024
Theoretical and Computational Biophysics Group, NIH Center for Macromolecular Modeling and Visualization, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana─Champaign, Urbana, Illinois 61801-3028, United States.
Diffusion of mobile charge carriers, such as ferredoxin and plastocyanin, often constitutes a rate-determining step in photosynthetic energy conversion. The diffusion time scales typically exceed that of other primary bioenergetic processes and remain beyond the reach of direct simulation at the molecular level. We characterize the diffusive kinetics of ferredoxin and plastocyanin upon the photosystem I-rich domain of , the most abundant phototroph on Earth by mass.
View Article and Find Full Text PDFInt J Numer Method Biomed Eng
January 2025
The Ferrara Center for Patient Safety and Clinical Simulation, New York Institute of Technology, College of Osteopathic Medicine, New York City, New York, USA.
The study findings demonstrate that the amniotic fluid plays an important role in protecting the fetus during convulsive maternal seizures. The amniotic fluid was found to be an effective buffer, significantly reducing the transfer of kinetic energy to the fetus during these events. This highlights the sufficient protection provided by the amniotic fluid in such circumstances.
View Article and Find Full Text PDFiScience
December 2024
Department of Anesthesiology, Yale School of Medicine, New Haven, CT 06510, USA.
Brain waste clearance from the interstitial fluid environment is challenging to measure, which has contributed to controversy regarding the significance of glymphatic transport impairment for neurodegenerative processes. Dynamic contrast enhanced MRI (DCE-MRI) with cerebrospinal fluid administration of Gd-tagged tracers is often used to assess glymphatic system function. We previously quantified glymphatic transport from DCE-MRI data utilizing regularized optimal mass transport (rOMT) analysis, however, information specific to glymphatic clearance was not directly derived.
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