Lipases: Valuable catalysts for dynamic kinetic resolutions.

Biotechnol Adv

Laboratory of Biocatalysis and Organic Synthesis, Universidade Federal do Rio de Janeiro, Instituto de Química, Cidade Universitária, Rio de Janeiro CEP21941909, Brazil.

Published: March 2016

Dynamic kinetic resolutions have proven to be a useful method for the preparation of enantiopure compounds from racemates, leading to the formation of a single enantiomer in theoretically 100% yield. Because lipases are ubiquitous, versatile, stereoselective and robust biocatalysts, they have been successfully applied as co-catalysts in these reactions, being mostly combined with metals in the chemoenzymatic dynamic kinetic resolutions of alcohols and amines.

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http://dx.doi.org/10.1016/j.biotechadv.2015.02.015DOI Listing

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