Purpose: Reflex human papillomavirus (HPV) testing is the preferred triage option for most women diagnosed with atypical squamous cells of undetermined significance (ASC-US). This study was conducted to describe follow-up results of women with ASC-US Pap test results in the National Breast and Cervical Cancer Early Detection Program (NBCCEDP), focusing on HPV test use.
Methods: We examined the follow-up of 45,049 women in the NBCCEDP with ASC-US Pap tests during 2009-2011. Data on demographic characteristics, diagnostic procedures, and clinical outcomes were analyzed.
Results: NBCCEDP providers diagnosed 45,049 women (4.5 % of all Pap tests) with an ASC-US result. Of those, 28,271 (62.8 %) were followed with an HPV test, 3,883 (8.6 %) with a repeat Pap test, 6,592 (14.6 %) with colposcopy, and 6,303 were lost to follow-up (14.0 %). Women aged 40 and older were followed more often with an HPV test. White, black, and Asian/Pacific Islander women were followed more often with an HPV test after an ASC-US Pap compared to Hispanic and American Indian/Alaska Native (AI/AN) women. Among women with a positive HPV test on follow-up, almost 90 % continued with colposcopy as recommended. AI/AN women had the highest rates of HPV positivity (55.2 %) and of no follow-up (25.0 %).
Conclusion: This is the first analysis describing follow-up of ASC-US Pap test results in the NBCCEDP, providing a window into current management of ASC-US results. Findings raise concerns about persistent disparities among AI/AN women. During 2009-2011, nearly two-thirds of women with an ASC-US Pap test result were followed with an HPV reflex test.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431899 | PMC |
| http://dx.doi.org/10.1007/s10552-015-0549-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Diagnostic Study Using STARD Platform on Liquid-Based Cytology in Cervical Smear and Its Positivity Rate among Females with Abnormal Vaginal Conditions Attending a Tertiary Care Center.
J Cytol
November 2024
Department of Physiotherapy, University Institute of Allied Health Sciences, Chandigarh University, Mohali, Punjab, India.
Background: Liquid-based cytology (LBC) is a newer method of preparing cervical cell samples. This technique involves collecting cells in a liquid fixative and preparing and evaluating them.
Aim: This study aims to investigate cervical smears prepared using the Ezi-Prep LBC method and analyze the positivity rate for cervical cancer and assess the diagnostic accuracy of LBC in detecting cervical abnormalities among females with abnormal vaginal conditions attending a tertiary care center.
Conservative management of cervical intraepithelial neoplasia 2 and prediction of its progression - a retrospective study.
Rom J Morphol Embryol
November 2024
Discipline of Ophthalmology, Department of Surgery II, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania; Department of Ophthalmology, Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania; Department of Obstetrics and Gynecology, Faculty of Medicine, Doctoral School, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania;
Aim: Cervical intraepithelial neoplasia 2 (CIN2) evolution is controversial, and some of them regress spontaneously in a two-year follow-up. The purpose of this work was to evaluate the percentage of CIN2 progression or persistence during a 24-month follow-up, using clinical predictors such as human papillomavirus (HPV) genotype and cytology results.
Patients, Materials And Methods: This is a retrospective case-control study and included patients of reproductive age who had a new diagnosis of CIN2 who were monitored for lesion regression (Group 1, n=72 patients), and progression or persistence (Group 2, n=36 patients).
Analysis of the sensitivity of high-grade squamous intraepithelial lesion Pap diagnosis and interobserver variability with the Hologic Genius Digital Diagnostics System.
Cancer Cytopathol
January 2025
Department of Pathology, UPMC Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Article Synopsis
High-risk human papillomavirus diversity among indigenous women of western Botswana with normal cervical cytology and dysplasia.
BMC Infect Dis
October 2024
Department of Pathology, Faculty of Medicine, University of Botswana, Gaborone, Botswana.
Article Synopsis
- Cervical cancer continues to be a significant public health challenge in Botswana, particularly among indigenous and marginalized groups, despite the introduction of a quadrivalent HPV vaccine and screening initiatives.
- A study involving 171 non-HPV vaccinated women aged 21 and older assessed the prevalence of high-risk HPV genotypes and cervical lesions through interviews, Pap smears, and HPV testing.
- The results revealed that 31% of participants were HIV positive, and 13.5% exhibited cervical dysplasia, with various atypical cell types identified, although no cases of high-grade lesions or cervical cancer were found.
Article Synopsis
- The study analyzed high-grade intraepithelial lesions (LIEHG) from 2010 to 2018 in a large population of asymptomatic women aged 25-65 who participated in a cervical cancer screening program.
- Out of 305,940 women, 3,230 were diagnosed with LIEHG, showing a prevalence of 0.4%, with detection rates significantly varying by age—particularly higher in women under 35.
- The results suggest that follow-up for low-grade smears is crucial and that adherence to screening recommendations lowers the risk of LIEHG, especially among younger women.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!