AI Article Synopsis
- The endoplasmic reticulum (ER) has quality control systems, including the unfolded protein response (UPR) and endoplasmic reticulum associated degradation (ERAD), that are crucial for cell function and organism survival.
- Recent research suggests that these quality-control systems in cancer cells can have mixed effects, aiding both tumor progression and prevention depending on the context.
- The review focuses on the relationship between ER proteostasis and cancer, highlighting key mechanisms like the IRE1α-XBP1 pathway of the UPR and the SEL1L-HRD1 complex of the ERAD.
Article Abstract
Quality control systems in the endoplasmic reticulum (ER) mediated by unfolded protein response (UPR) and endoplasmic reticulum associated degradation (ERAD) ensure cellular function and organismal survival. Recent studies have suggested that ER quality-control systems in cancer cells may serve as a double-edged sword that aids progression as well as prevention of tumor growth in a context-dependent manner. Here we review recent advances in our understanding of the complex relationship between ER proteostasis and cancer pathology, with a focus on the two most conserved ER quality-control mechanisms--the IRE1α-XBP1 pathway of the UPR and SEL1L-HRD1 complex of the ERAD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523434 | PMC |
| http://dx.doi.org/10.1016/j.semcancer.2015.02.003 | DOI Listing |
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