AI Article Synopsis
- - The XRCC3 gene, particularly the rs861539 (Thr241Met) polymorphism, has been frequently studied for its potential link to lung cancer risk, but results across various populations remain inconsistent.
- - A systematic review and meta-analysis of 21 studies involving nearly 14,000 participants were conducted, finding no significant association between the XRCC3 Thr241Met variant and lung cancer risk across different genetic models and ethnic groups.
- - The findings suggest no strong evidence supporting the connection between this specific gene variant and lung cancer risk; future research should explore gene-gene interactions for a better understanding of lung cancer susceptibility.
Article Abstract
Background: The X-ray repair cross-complementing group 3 (XRCC3) is a highly suspected candidate gene for cancer susceptibility, and a large amount studies have examined the association of the rs861539 in XRCC3 (Thr241Met) with lung cancer risk in various populations. However, the results remain inconclusive.
Methods: The electronic database of PubMed, Medline, Embase and CNKI (China National Knowledge Infrastructure) were searched for case-control studies published up to December 05, 2013. A systematic review and meta-analysis was performed to evaluate the relationship between XRCC3 Thr241Met polymorphism and lung cancer risk. Data were extracted and pooled odds ratio (OR) with its 95% confidence intervals (CI) were calculated.
Results: Total 21 studies, including 6880 lung cancer cases and 8329 controls, were available for meta-analysis. Overall, our results showed that the XRCC3 Thr241Met polymorphism was not associated with risk of lung cancer in all genetic contrast models (P>0.05). Stratified analyses by ethnicity (Asians, Caucasians and mixed population) showed similar results. Additionally, no evidence of publication bias was observed by using the funnel plot.
Conclusions: There is no clear evidence showing a significant correlation between XRCC3 Thr241Met polymorphism and lung cancer risk in total population and stratified analysis by ethnicity. However, studies assessing the gene-gene interactions should be considered to further estimate this gene variant in lung cancer risk.
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| http://dx.doi.org/10.1016/j.bulcan.2015.02.003 | DOI Listing |
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