The present study aimed to clarify the effects of inspiratory muscle training (IMT) and expiratory muscle training (EMT) on ventilatory muscle strength, pulmonary function and responses during exercise testing. Young healthy women were randomly assigned to 3 groups: IMT (n=16); EMT (n=16); or untrained normal controls (NC, n=8). Subjects in the IMT and EMT groups trained for 15 minutes twice daily over 2 weeks at loads of 30% maximal inspiratory and expiratory muscle strength, respectively. Ventilatory muscle strength (maximal inspiratory and expiratory muscle strength; PImax and PEmax, respectively), pulmonary function and progressive exercise testing was performed. Both PImax and PEmax increased in the IMT group, and PEmax increased in the EMT group. Neither trained group demonstrated any change in pulmonary function or peak values during exercise testing. In the IMT group, exercise-induced increases in heart rate, oxygen uptake (VO2/kg) and rating of perceived exertion (RPE) decreased with training, as did increases in VO2/kg and RPE in the EMT group. The increased ventilatory muscle strength in both IMT and EMT groups might improve ventilatory efficacy during exercise, and increased inspiratory muscle strength might facilitate oxygen delivery through improved circulatory responses.
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http://dx.doi.org/10.1298/jjpta.8.29 | DOI Listing |
Pulmonology
December 2025
Laboratory of Experimental Therapeutics, LIM-20, Department of Clinical Medicine, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Background: Chronic obstructive pulmonary disease (COPD) induces an imbalance in T helper (Th) 17/regulatory T (Treg) cells that contributes to of the dysregulation of inflammation. Exercise training can modulate the immune response in healthy subjects.
Objective: We aimed to evaluate the effects of exercise training on Th17/Treg responses and the differentiation of Treg phenotypes in individuals with COPD.
Although current treatments for Duchenne Muscular Dystrophy (DMD) have proven to be effective in delaying myopathy, there remains a strong need to identify novel targets to develop additional therapies. Mitochondrial dysfunction is an early pathological feature of DMD. A fine balance of mitochondrial dynamics (fission and fusion) is crucial to maintain mitochondrial function and skeletal muscle health.
View Article and Find Full Text PDFFront Rehabil Sci
December 2024
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Osteoporotic vertebral fractures (OVFs) significantly impair the quality of life in older adults. Spinal orthoses are commonly used, but their effectiveness is debated. Thus, we aimed to evaluate the impact of different spinal orthoses on pain, functionality, and quality of life in patients with OVFs.
View Article and Find Full Text PDFTransl Sports Med
December 2024
Department of Orthopaedic Surgery, Institute of Sports Medicine Copenhagen, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark.
Persisting deficits are often seen years after an Achilles tendon rupture despite dedicated rehabilitation efforts. A possible reason for reduced function is elongation of the tendon and accompanying shortening of the muscle. Strength training with focus on the eccentric component of loading leads to longer muscle fascicles in healthy persons.
View Article and Find Full Text PDFPsychogeriatrics
January 2025
Kastamonu Training and Research Hospital, Division of Rheumatology, University of Health Sciences, Kastamonu, Turkey.
Purpose: This study aims to compare the prevalence of depression and related geriatric syndromes in earlier-onset rheumatoid arthritis (EORA) patients, who have experienced prolonged inflammation and medication use, with those with late-onset rheumatoid arthritis (LORA) patients, who often present with an acute and severe course.
Methods: In this multidisciplinary study, patients with EORA and LORA aged 60 and over who were referred to a tertiary rheumatology clinic underwent a geronto-rheumatologic evaluation. Muscle mass and handgrip strength, cognitive function, nutritional status, Fried frailty index, fall history, gait speed, depression according to Geriatric Depression Scale and Insomnia Severity Index were recorded.
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