AI Article Synopsis
- The study aimed to examine how reloading affects atrophied muscle in rats and the timing of muscle growth and recovery.
- It involved 49 male Wistar rats, divided into groups for hindlimb suspension, reloading, and control, with reloading times ranging from 1 to 14 days after 14 days of suspension.
- Findings showed that muscle growth and recovery processes were not uniform, with significant improvements in muscle size and myonuclear domain size only occurring after 7 days of reloading, highlighting the importance of timing in physiotherapeutic interventions.
Article Abstract
The purpose of this study was to investigate the effect of reloading on atrophied muscle and the time course of hypertrophy and regeneration. Forty-nine male Wistar rats were randomly assigned to groups for hindlimb suspension (HS), hindlimb suspension and reloading (R), or control (C0). Rats in the HS group were suspended for 14 days. Rats in the R group were randomly divided into five subgroups for different post-hindlimb-suspension recovery times. Briefly, each subgroup was suspended for 14 days and given 1 day of reloading (R1), 3 days of reloading (R3), 7 days of reloading (R7), 10 days of reloading (R10), or 14 days of reloading (R14). Myonuclear numbers were significantly decreased in the groups with hindlimb suspension and 1 day and 3 days of reloading compared with that in the control group. We focused on the processes of change of mean myofiber cross-sectional area and myonuclear domain size; the degrees of increase of both indexes were limited until 3 days of reloading, and significantly increased after 7 days of reloading. An important finding of the current study was that the processes of muscle hypertrophy and regeneration did not show uniform change. In addition, there were differences in the ratio of increase among the stages of hypertrophy and regeneration. Therefore, consideration of the duration and method of physiotherapeutic intervention for atrophied muscle on the basis of the process of hypertrophy and regeneration is needed to provide more effective physiotherapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316541 | PMC |
| http://dx.doi.org/10.1298/jjpta.Vol15_001 | DOI Listing |
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