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Management of patients with recurrent glioblastoma using hypofractionated stereotactic radiotherapy. | LitMetric

AI Article Synopsis

  • Glioblastoma (GBM) is a challenging brain tumor with poor prognosis, and this study reviewed the effectiveness of hypofractionated stereotactic radiotherapy (HFSRT) for patients with recurrent GBM.
  • Twenty-eight patients were treated with a total dose of 25 Gy over 5 days, and their outcomes were evaluated based on variables such as age, tumor size, and overall health status.
  • Results indicated that HFSRT is a viable treatment option, with median overall survival of 10.3 months influenced by factors like longer time before recurrence, smaller tumor size, better performance status, and younger age.

Article Abstract

Background: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. The chance of cure is very limited due to treatment-refractory disease course with frequent recurrences despite aggressive multimodality management. In this retrospective study, we evaluated treatment outcomes of hypofractionated stereotactic radiotherapy (HFSRT) in the management of recurrent GBM and report our single-center experience.

Methods: Twenty-eight patients receiving HFSRT for recurrent GBM between September 2008 and February 2014 were retrospectively assessed. Total radiotherapy dose was 25 Gy delivered in 5 fractions over 5 consecutive days for all patients. High-precision, image-guided volumetric modulated arc therapy was delivered with a linear accelerator using 6-MV photons using the frameless technique. Analyzed prognostic factors were age, gender, Karnofsky performance status (KPS), tumor location, planning target volume (PTV) size, overall survival (OS), progression-free survival (PFS), time interval between completion of treatment with Stupp protocol at primary diagnosis and recurrence.

Results: Median follow-up time was 42 months (range 2-68). Median time interval between primary chemoradiotherapy and HFSRT was 11.2 months (range 4-57.9). Median OS and PFS calculated from reirradiation was 10.3 months and 5.8 months, respectively. Longer interval between initial treatment and recurrence (p = 0.01), smaller PTV size (p = 0.001), KPS ≥70 (p = 0.005) and younger age (p = 0.004) were associated with longer OS on statistical analysis.

Conclusion: HFSRT offers a feasible and effective salvage treatment option for recurrent GBM management. Prognostic factors associated with longer OS in our study were longer interval between initial treatment and recurrence, smaller PTV size, KPS ≥70 and younger age.

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Source
http://dx.doi.org/10.5301/tj.5000236DOI Listing

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