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Macrophage activation syndrome with acute hepatitis E during tocilizumab treatment for rheumatoid arthritis. | LitMetric

Macrophage activation syndrome with acute hepatitis E during tocilizumab treatment for rheumatoid arthritis.

Joint Bone Spine

Service de rhumatologie, hôpital Sud, CHU de Rennes, 16, boulevard de Bulgarie, BP90347, 35203 Rennes cedex 2, France.

Published: July 2015

AI Article Synopsis

Article Abstract

Tocilizumab is a humanized antibody against the membrane and soluble receptors for interleukin-6. Tocilizumab is among the disease-modifying antirheumatic drugs (DMARDs) used to treat moderate-to-severe active rheumatoid arthritis (RA) refractory to conventional DMARDs. We report a case of macrophage activation syndrome that complicated acute hepatitis E and started within 24hours after the fourth tocilizumab infusion in a patient with RA.

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Source
http://dx.doi.org/10.1016/j.jbspin.2015.01.018DOI Listing

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