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Identification of novel serum lipid metabolism potential markers and metabolic pathways for oral cancer: a population-based study.
BMC Cancer
January 2025
Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, 1 Xueyuan Road, Fujian, 350108, China.
Objective: This study aims to identify potential lipid biomarkers and metabolic pathways associated with oral cancer (OC). Then to establish and evaluate disease classification models capable of distinguishing OC patients from healthy controls.
Methods: A total of 41 OC patients and 41 controls were recruited from a hospital in Southeast China to examine the serum lipidomics by Ultra-high Performance Liquid Chromatography Q Exactive Mass Spectrometry (UHPLC-QE-MS).
Computational Elucidation of Hub Genes and Pathways Correlated with the Development of 5-Fluorouracil Resistance in HCT 116 Colorectal Carcinoma Cell Line.
Biochem Genet
January 2025
Institute of Biological Sciences, Faculty of Science, Universiti Malaya, 50603, Kuala Lumpur, Malaysia.
Colorectal cancer (CRC) is the third most deadly cancer diagnosed in both men and women. 5-Fluorouracil (5-FU) treatment frequently causes the CRC cells to become chemoresistance, which has a negative impact on prognosis. Using bioinformatic techniques, this work describes important genes and biological pathways linked to 5-FU resistance in CRC cells.
View Article and Find Full Text PDFCharacteristics associated with career self-reliance behaviors of nurses working in nursing homes in Japan: A cross-sectional study.
Belitung Nurs J
January 2025
Gifu College of Nursing, Egira-cho, Hashima City, Gifu Prefecture, 501-6295, Japan.
Background: With an aging global population, establishing integrated systems for long-term care is challenging in several countries. Adequate and quality service for older adults in nursing homes can improve their quality of life. The career self-reliance of nurses working in nursing homes may affect the quality of life of older adults; this suggests a need for educational support for career self-reliance behavior.
View Article and Find Full Text PDFAnalysis of factors influencing length of stay in the emergency department in public hospital, Padang, Indonesia.
Med J Armed Forces India
January 2024
Student in Bachelor of Nursing, Faculty of Nursing, Universitas Andalas, Padang, Indonesia.
Background: Extending the time patients spend in the emergency department (ED) not only diminishes the quality of care but also heightens the potential for harm and adversely impacts patient satisfaction. However, there exists a dearth of accessible information regarding the length of stay (LOS) in emergency departments and the factors associated with it in Indonesia. This study aims to analyze the factors that influence the LOS of patients in the emergency department of a public hospital in Padang, Indonesia.
View Article and Find Full Text PDFEffects of acteoside from on the plasma metabolome of cancer-related fatigue mice inoculated with colon cancer cells.
Front Pharmacol
January 2025
Department of Pharmacognosy, School of Pharmacy, Xinjiang Medical University, Urumqi, China.
Objective: To elucidate the metabolic mechanisms by which acteoside (ACT) isolated from alleviates cancer-related fatigue (CRF) in a murine model of colon cancer with cachexia.
Methods: BALB/c mice inoculated with C26 colon cancer cells were treated with paclitaxel (PTX, 10 mg/kg) and ACT (100 mg/kg) alone or in combination for 21 days. Fatigue-associated behaviors, tumor inhibition rate, and skeletal muscle morphology assessed by hematoxylin-eosin (H&E) staining and electron microscopy were evaluated.
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