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Exploring genetics and genomics trends to understand the link between secondary metabolic genes and agronomic traits in cereals under stress.
J Plant Physiol
December 2024
Department of Biotechnology, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India. Electronic address:
The plant metabolome is considered an important interface between the genome and its phenome, where it plays a significant role in regulating plant growth in response to various environmental cues. A wide array of specialized metabolites is produced by plants, which are essential for mediating environmental interactions and their adaptation. Notably, enhanced accumulation of these specialized metabolites, particularly plant secondary metabolites (PSMs), is a part of the chemical defense response that is directly linked to improved stress tolerance.
View Article and Find Full Text PDFRadiotherapy and breast cancer: finally, an lncRNA perspective on radiosensitivity and radioresistance.
Front Oncol
September 2024
Department of Biology, College of Science, Mathematics, and Technology, Wenzhou-Kean University, Wenzhou, China.
Radiotherapy (RT) serves as one of the key adjuvant treatments in management of breast cancer. Nevertheless, RT has two major problems: side effects and radioresistance. Given that patients respond differently to RT, it is imperative to understand the molecular mechanisms underlying these differences.
View Article and Find Full Text PDFA Review of the Regulatory Challenges of Personalized Medicine.
Cureus
August 2024
Pharmacy, SRM College of Pharmacy, SRM Institute of Science and Technology (SRMIST), Chennai, IND.
Personalized medicine integrates genomics with clinical and familial histories, revolutionizing healthcare by tailoring treatments to individual patient characteristics. At its core, pharmacogenomics enables the customization of medication prescriptions based on genetic profiles, enhancing drug efficacy and safety. This precision medicine approach addresses disease diagnosis, prevention, and treatment, offering targeted therapies for conditions like autoimmune disorders, rheumatoid arthritis, and neoplastic conditions.
View Article and Find Full Text PDFSystemic Therapy in Breast Cancer.
Am Soc Clin Oncol Educ Book
June 2024
Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL.
Therapeutic advances in breast cancer have significantly improved outcomes in recent decades. In the early setting, there has been a gradual shift from adjuvant-only to neoadjuvant strategies, with a growing focus on customizing post-neoadjuvant treatments through escalation and de-escalation based on pathologic response. At the same time, the transition from a pre-genomic to a post-genomic era, utilizing specific assays in the adjuvant setting and targeted sequencing in the advanced stage, has deepened our understanding of disease biology and aided in identifying molecular markers associated with treatment benefit.
View Article and Find Full Text PDFThe rising prevalence of antibiotic resistance threatens human health. While more sophisticated strategies for antibiotic discovery are being developed, target elucidation of new chemical entities remains challenging. In the post-genomic era, expression profiling can play an important role in mechanism-of-action (MOA) prediction by reporting on the cellular response to perturbation.
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