A new isocoumarin derivative, similanpyrone C (1), a new cyclohexapeptide, similanamide (2), and a new pyripyropene derivative, named pyripyropene T (3) were isolated from the ethyl acetate extract of the culture of the marine sponge-associated fungus Aspergillus similanensis KUFA 0013. The structures of the compounds were established based on 1D and 2D NMR spectral analysis, and in the case of compound 2 the stereochemistry of its amino acid constituents was determined by chiral HPLC analysis of the hydrolysate by co-injection with the d and l amino acids standards. Compounds 2 and 3 were evaluated for their in vitro growth inhibitory activity against MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A373 (melanoma) cell lines, as well as antibacterial activity against reference strains and the environmental multidrug-resistant isolates (MRS and VRE). Only compound 2 exhibited weak activity against the three cancer cell lines, and neither of them showed antibacterial activity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377992 | PMC |
| http://dx.doi.org/10.3390/md13031432 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Vicinal Bis(methylene) Heterocyclic Diene in Natural Product Synthesis: A Convergent Biomimetic Total Synthesis of Prunolactone A.
Org Lett
December 2024
Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
Article Synopsis
- The researchers successfully synthesized the natural compound prunolactone A and its unnatural epimer in 10 and 8 steps, respectively.
- The synthesis involved creating a key reactive intermediate and using a biomimetic Diels-Alder reaction to combine it with scytolide derivatives.
- Computational analysis supported the selectivity of the Diels-Alder reaction, highlighting the techniques used to achieve stereochemical purity.
Risk assessment of Ochratoxin A (OTA) exposure from coffee consumption in Indonesia using Margin of Exposure (MOE) approach.
Food Chem Toxicol
January 2025
Department of Food Technology, School of Life Sciences, Indonesia International Institute for Life Sciences, Jakarta, 13210, Indonesia.
Article Synopsis
- Ochratoxin A (OTA) is a harmful mycotoxin found in food, particularly in coffee, and poses potential health risks to humans, especially in Indonesia.
- Indonesia faces challenges in controlling OTA contamination in coffee due to favorable fungal growth conditions and poor food safety practices.
- The study uses the Margin of Exposure (MOE) approach to assess the risk of OTA exposure from coffee, finding that many provinces in Indonesia have concerningly low MOE values, highlighting the need for better food safety management in coffee production.
Recent advances in the structures and bioactivities of benzopyrans derived from marine fungi: a review.
Front Pharmacol
October 2024
School of Pharmacy, Jining Medical University, Rizhao, China.
Marine fungi represent a treasure trove of bioactive secondary metabolites, with benzopyran compounds emerging as a significant class of these natural products. This review delves into the structural diversity, biological activities, and sources of benzopyran compounds, highlighting their isolation from marine fungi inhabiting diverse environments such as sponges, marine sediments, algae, mangroves, and corals. Our literature search, conducted from 2000 to 2023, has identified a wealth of benzopyran compounds, showcasing their potential as lead compounds in drug development.
View Article and Find Full Text PDFHighly efficient electrochemiluminescent properties of porphyrin-based metal-organic framework Zn-TCPP and its immunoassay application to the detection of ochratoxin A.
Anal Chim Acta
November 2024
The Key Lab of Health Chemistry & Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering & Materials Science, Soochow University, Suzhou, 215123, PR China; Center of Self-Propelled Nanotechnologies, Suzhou Industrial Park Institute of Services Outsourcing, Suzhou, 215123, PR China. Electronic address:
Article Synopsis
- Ochratoxin A (OTA) is a harmful mycotoxin found in food that poses health risks, making its detection in cereal-based foods crucial.
- A novel sensor was developed using zinc-tetrakis (4-carboxyphenyl) porphyrin (Zn-TCPP) nanorods and BiS@Au nanoflowers, which enhanced luminescence signals and allowed for the ultra-sensitive detection of OTA in various food samples.
- This innovative approach not only effectively detects OTA at very low concentrations (as low as 0.13 pg/mL) but also offers a promising research avenue for analyzing other mycotoxins and advancing the study of metal-organic frameworks.
New Isocoumarins from an Endophytic Fungal Strain Diaporthe arengae M2 and their Antibacterial Activities.
Chem Biodivers
October 2024
Haikou Key Laboratory for Research and Utilization of Tropical Natural Products & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, 571101, China.
Four new isocoumarin derivatives 12-O-acetyl-isocitreoisocoumarinol (1), (+)-(10R)-O-acetyl-diaportinol (2-a), (-)-(10S)-O-acetyl-diaportinol (2-b), peyroisocoumarin E (3) and new stereoconfigurations of three isocoumarin derivatives desmethyldichlorodiaportinol A (4), threo-monochlorodiaportinol A (5-a), erytheo-monochlorodiaportinol A (5-b), together with nine known ones (6-14), were separated from the rice fermentation of endophytic fungus Diaporthe arengae M2 isolated from Camellia oleifera. The structures of new compounds were determined by extensive spectroscopic analyses including nuclear magnetic resonance (NMR) and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Compounds 4, 7, 8, 12, 13 exhibited definite inhibition against five strains of bacteria with the MIC values range from 16 μg/mL to 64 μg/mL.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!