Objective: The aim of this study is to investigate urine fluoride concentration as a toxicity factor in a rural community in the state of San Luis Potosi, Mexico.
Materials And Methods: A sample of 111 children exposed to high concentrations of fluoride in drinking water (4.13 mg/L) was evaluated. Fluoride exposure was determined by measuring urine fluoride concentration using the potentiometric method with an ion selective electrode. The diagnosis of dental fluorosis was performed by clinical examination, and the severity of damage was determined using Dean's index and the Thylstrup-Fejerskov (TF) index.
Results: The range of exposure in the study population, evaluated through the fluoride content in urine, was 1.1 to 5.9 mg/L, with a mean of 3.14±1.09 mg/L. Dental fluorosis was present in all subjects, of which 95% had severe cases. Higher urine fluoride levels and greater degrees of severity occurred in older children.
Conclusions: The results show that dental fluorosis was determined by the presence of fluoride exposure finding a high positive correlation between the severity of fluorosis and urine fluoride concentration and the years of exposure suggested a cumulative effect.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350618 | PMC |
| http://dx.doi.org/10.1155/2015/647184 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fluoride Exposure and Children's IQ Scores: A Systematic Review and Meta-Analysis.
JAMA Pediatr
January 2025
Division of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Importance: Previous meta-analyses suggest that fluoride exposure is adversely associated with children's IQ scores. An individual's total fluoride exposure comes primarily from fluoride in drinking water, food, and beverages.
Objective: To perform a systematic review and meta-analysis of epidemiological studies investigating children's IQ scores and prenatal or postnatal fluoride exposure.
The potential of urinary miR-200c-3p as a biomarker of fluorosis in rats.
Ecotoxicol Environ Saf
January 2025
Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China. Electronic address:
Fluorine is a strong oxidizing element and excessive intake can have harmful effects, particularly on the body's calcified tissues. Recent studies have demonstrated a link between miRNA and fluorosis. This study aimed to evaluate the time-dose-effect relationship of miR-200c-3p in plasma, urine and cartilage of rats with drinking water fluorosis, and to explore its potential as a biomarker.
View Article and Find Full Text PDFEffects of high fluoride and iodine combined exposure on thyroid nodules and goiter in school-age children in Jiangsu, China.
Heliyon
November 2024
Department for Environmental Health (Endemic Disease Control and Prevention), Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu Road 172, 210009 Nanjing, PR China.
Introduction: With advancements in detection equipment and an increase in the frequency of examinations, thyroid nodules and goiter in children have garnered attention.
Objective: This study aims to determine the effects of high iodine and fluoride exposure on thyroid nodules and goiter in school-aged children.
Methods: We recruited children aged 8 to 12 from rural Jiangsu, China, based on the concentrations of iodine and fluoride in local drinking water and urine.
Determination of endogenous GHB in ante-mortem whole blood, urine, and oral fluid by LC-MS/MS: The effect of different additives and storage conditions on the stability of GHB in blood.
Forensic Sci Int
December 2024
Section for Forensic Chemistry, Department of Forensic Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N 8200, Denmark.
Article Synopsis
- This study aimed to develop a method for detecting γ-hydroxybutyric acid (GHB) in human blood, urine, and oral fluid while accounting for its naturally occurring presence and potential in vitro production after sampling.
- Researchers validated an LC-MS/MS method with a low limit of quantification (0.005 µg/mL in blood and 0.010 µg/mL in urine/oral fluid), achieving high extraction recovery rates and minimal bias.
- Stability tests showed that GHB concentrations change over time in different blood preservatives, indicating that current detection cut-off levels for GHB might need to be adjusted, especially for samples stored at -20°C.
Association of perinatal exposition to xenobiotics with kidney volume at birth.
Nephrol Dial Transplant
October 2024
Department of Nephrology, Hospital Centenario Miguel Hidalgo.
Article Synopsis
- Aguascalientes has a high rate of kidney failure in young adults, potentially linked to low kidney volume (KV) at birth and exposure to harmful substances (xenobiotics).
- The study involved 299 healthy pregnant women, analyzing their urine, amniotic fluid, and their newborns' urine to measure various toxic metals and pesticides, alongside calculating the total kidney volume.
- Results indicated that exposure to specific pesticides and fluoride during pregnancy correlated with low kidney volume in infants, suggesting a possible connection to kidney health issues and electrolyte imbalances.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!