AI Article Synopsis
- Nephrotic syndrome (NS) is a kidney disorder characterized by protein loss in urine, low albumin levels, swelling, and high lipid levels, affecting individuals of all ages and possibly leading to severe kidney disease.
- The pathophysiology of NS remains unclear, but the immune system is believed to play a crucial role, and animal models, particularly Doxorubicin-induced NS in rodents, are valuable for research purposes.
- This review focuses on the Doxorubicin model, highlighting how the drug works, mechanisms of kidney damage, and the resulting biochemical and structural changes observed in this experimental setup.
Article Abstract
Nephrotic syndrome (NS) is characterized by proteinuria, hypoalbuminemia, generalized edema, and hyperlipidemia. It begins by changes in the glomerular filtration barrier, with increased permeability to plasma proteins. It affects all age groups and can progress to end-stage renal disease. NS pathophysiology is still unknown. However, the critical role of the immune system is well recognized. Animal models are useful tools for the investigation of NS. Among different experimental models proposed in the literature, disease induced by Doxorubicin has been considered helpful to the purpose of many studies. The aim of this review article is to describe the animal model of NS induced by the injection of Doxorubicin in rodents, with emphasis on action of the drug, potential mechanisms of renal injury, as well biochemical, histological, and corporal changes obtained with this model.
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