Cigarette smoke resets the Alarmin IL-33 in COPD.

Immunity

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK; School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215006, China. Electronic address:

Published: March 2015

Cigarette smoke and infection are the major drivers of chronic obstructive pulmonary disease. In this issue of Immunity, Kearley et al. (2015) demonstrate that smoke exposure alters the lung microenvironment leading to an interleukin-33-dependent proinflammatory disease exacerbation.

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Source
http://dx.doi.org/10.1016/j.immuni.2015.02.014DOI Listing

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