A ratiometric fluorescent probe for in situ quantification of basal mitochondrial hypochlorite in cancer cells.

Chem Commun (Camb)

Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry Sichuan University, 29, Wangjiang Road, Chengdu, Sichuan Province, P. R. China.

Published: April 2015

A ratiometric fluorescent probe () for ClO(-) based on the conjugate of coumarin-rhodamine was presented, which could sense ClO(-) with fast response (within 5 s), high sensitivity and excellent selectivity. More importantly, is the first mitochondria-targeted ratiometric fluorescent probe to image exogenous and endogenous ClO(-).

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http://dx.doi.org/10.1039/c5cc01217aDOI Listing

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