Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363876 | PMC |
| http://dx.doi.org/10.7554/eLife.07482 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unbiased picture of the ligand docking process for the hevein protein-oligosaccharide complex.
Sci Rep
January 2025
Department of Applied Chemistry, Faculty of Engineering, University of Miyazaki, 1-1 Nishi, Gakuen-Kibanadai, Miyazaki, 889-2192, Japan.
The ligand-docking behavior of hevein, the major latex protein from the rubber tree Hevea brasiliensis (Euphorbiaceae), has been investigated by the unguided molecular dynamics (MD) simulation method. An oligosaccharide molecule, initially placed in an arbitrary position, was allowed to move around hevein for a prolonged simulation time, on the order of microseconds, with the expectation of spontaneous ligand docking of the oligosaccharide molecule to the binding site of hevein. In the binary solution system consisting of a hevein molecule and a chito-trisaccharide (GlcNAc) molecule, three out of the six separate simulation runs successfully reproduced the complex structure of the observed binding from.
View Article and Find Full Text PDFReorganization of gray matter networks in patients with Moyamoya disease.
Sci Rep
January 2025
Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Patients with Moyamoya disease (MMD) exhibit significant alterations in brain structure and function, but knowledge regarding gray matter networks is limited. The study enrolled 136 MMD patients and 99 healthy controls (HCs). Clinical characteristics and gray matter network topology were analyzed.
View Article and Find Full Text PDFThe Alteration of Brain Network Topology in Tinnitus Transition From Recent-Onset to Chronic.
Eur J Neurosci
January 2025
Department of Radiology, Henan Provincial People's Hospital and Zhengzhou University People's Hospital, Zhengzhou, China.
The occurrence and persistence of tinnitus result from the interaction of multiple neural networks. This study aims to explore the alterations in brain network topology associated with the transition of tinnitus from recent-onset to chronic. Twenty-eight patients with chronic tinnitus, 28 patients with recent-onset tinnitus and 28 sex- and age-matched healthy controls (HC) were enrolled in this study.
View Article and Find Full Text PDFEffects of local mutations in quadratic iterations.
Chaos
January 2025
Department of Mathematics, Iowa State University, Ames, Iowa 50011, USA.
We introduce mutations in the process of discrete iterations of complex quadratic maps in the family fc(z)=z2+c. More specifically, we consider a "correct" function fc1 acting on the complex plane. A "mutation" fc0 is a different ("erroneous") map acting on a locus of given radius r around a mutation focal point ξ∗.
View Article and Find Full Text PDFA simple phylogenetic approach to analyze hypermutated HIV proviruses reveals insights into their dynamics and persistence during antiretroviral therapy.
Virus Evol
November 2024
Faculty of Health Sciences, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.
Hypermutated proviruses, which arise in a single Human Immunodeficiency Virus (HIV) replication cycle when host antiviral APOBEC3 proteins introduce extensive guanine to adenine mutations throughout the viral genome, persist in all people living with HIV receiving antiretroviral therapy (ART). However, hypermutated sequences are routinely excluded from phylogenetic trees because their extensive mutations complicate phylogenetic inference, and as a result, we know relatively little about their within-host evolutionary origins and dynamics. Using >1400 longitudinal single-genome-amplified HIV sequences isolated from six women over a median of 18 years of follow-up-including plasma HIV RNA sequences collected over a median of 9 years between seroconversion and ART initiation, and >500 proviruses isolated over a median of 9 years on ART-we evaluated three approaches for masking hypermutation in nucleotide alignments.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!