Refractory rheumatic disorder: atypical postpregnancy osteoporosis.

Case Rep Rheumatol

CHU Gabriel Montpied, Service de Rhumatologie, 58 rue Montalembert, 63000 Clermont-Ferrand, France.

Published: March 2015

AI Article Synopsis

  • The case involves a young pregnant patient who experienced severe osteoporosis symptoms, initially mistaken for arthritis during her second pregnancy.
  • Postpartum, her pain worsened despite normal X-ray results, leading to further imaging that eventually revealed multiple fractures.
  • After extensive testing failed to identify a secondary cause, the patient was diagnosed with postpregnancy osteoporosis and began treatment with teriparatide, suggesting that this condition may be more common than previously recognized.

Article Abstract

This is a case report on a young patient with severe osteoporosis that was initially revealed when she presented with polyarthralgia during her second pregnancy. Postpartum, the pain increased and her X-ray did not show any abnormalities. A bone scintigraphy was performed. It indicated an inflammatory rheumatic disorder. Six months after partum, an investigation of right coxalgia revealed a spontaneous basicervical fracture. Given the persistent polyarthralgia, the patient underwent a new scintigraphy, which revealed areas of what looked to be old rib and L1 fractures. A subsequent full body magnetic resonance imaging (MRI) scan revealed signal abnormalities that could indicate multiple lower limb bone fractures. Despite exhaustive biological, radiological, and histological testing, no secondary cause for the osteoporosis was found. The patient was started on teriparatide. We finally concluded that, despite the atypical presentation, the patient was suffering from postpregnancy osteoporosis. It is possible that the frequency of occurrence of this still poorly understood disease is underestimated.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346694PMC
http://dx.doi.org/10.1155/2015/327965DOI Listing

Publication Analysis

Top Keywords

rheumatic disorder
8
postpregnancy osteoporosis
8
refractory rheumatic
4
disorder atypical
4
atypical postpregnancy
4
osteoporosis
4
osteoporosis case
4
case report
4
report young
4
patient
4

Similar Publications

This study aimed to investigate the association between the interleukin-1 beta (IL-1β) gene polymorphism (rs2853550) and the risk of rheumatoid arthritis (RA) in a sample of the Iraqi population. The study included 100 RA patients and 100 healthy controls. Demographic characteristics, including age and gender, were collected and compared between the two groups.

View Article and Find Full Text PDF

A prediction study on the occurrence risk of heart disease in older hypertensive patients based on machine learning.

BMC Geriatr

January 2025

Department of Cardiology, The Second Hospital & Clinical Medical School, Lanzhou University, No. 82 Cuiyingmen, Lanzhou, 730000, China.

Objective: Constructing a predictive model for the occurrence of heart disease in elderly hypertensive individuals, aiming to provide early risk identification.

Methods: A total of 934 participants aged 60 and above from the China Health and Retirement Longitudinal Study with a 7-year follow-up (2011-2018) were included. Machine learning methods (logistic regression, XGBoost, DNN) were employed to build a model predicting heart disease risk in hypertensive patients.

View Article and Find Full Text PDF

Knee osteoarthritis (KOA) represents a progressive degenerative disorder characterized by the gradual erosion of articular cartilage. This study aimed to develop and validate biomarker-based predictive models for KOA diagnosis using machine learning techniques. Clinical data from 2594 samples were obtained and stratified into training and validation datasets in a 7:3 ratio.

View Article and Find Full Text PDF

Axial spondyloarthritis manifests as a chronic inflammatory disease primarily affecting the sacroiliac joints and spine. Although chronic back pain and spinal stiffness are typical initial symptoms, peripheral (ie, enthesitis, arthritis, and dactylitis) and extra-musculoskeletal (ie, uveitis, inflammatory bowel disease, and psoriasis) manifestations are also common. Timely and accurate diagnosis is challenging and relies on identifying a clinical pattern with a combination of clinical, laboratory (HLA-B27 positivity), and imaging findings (eg, structural damage on pelvic radiographs and bone marrow oedema on MRI of the sacroiliac joints).

View Article and Find Full Text PDF

Background: Surgical management of patients with severe aortic regurgitation (AR) in the setting of significantly impaired left ventricle (LV) function generally carries very high operative risk. The aim of this study is to assess the short and long-term outcomes of aortic valve replacement (AVR) in a selected young Moroccan population.

Materiel And Methods: This is a retrospective study between January 2008 and June 2022 including all patients who underwent AVR for massive isolated AR with an LV ejection fraction EF ≤35%.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!