We investigated the effect of a neuropeptide, substance P, on the electrical and ion transport properties of dog trachea. Posterior mucosal tissues were mounted in Ussing chambers and bathed with Krebs-Henseleit solution, pH 7.4, at 37 degrees C. The solution was gassed with 95% O2, 5% CO2. Substance P (10(-7)M) added to the mucosal bath elicited within seconds a rapid rise in short circuit current with a peak response of 23 microA.cm-2 and an increase in tissue conductance of 0.63 mS.cm-2 (p less than 0.001, n = 20). In 6 experiments, 36Cl and 22Na fluxes were measured under short circuit conditions and they revealed that net Cl secretion increased from 1.46 +/- 0.41 to 2.30 +/- 0.74 mueq.cm-2 X h-1 (mean +/- SE, p less than 0.05). This increase was brought about by enhancement of unidirectional submucosa to lumen flux. Net Na absorption of 0.63 +/- 0.09 did not change significantly (0.49 +/- 0.16). Short circuit current response to substance P was not modified by prior tissue incubation with atropine, phenoxybenzamine, propranolol, or naloxone. Removal of mucosal bath calcium and the presence of calcium channel blocker verapamil did not abolish tissue response to substance P. These findings suggest that nerve fibers containing substance P may play a role in regulation of ion transport across the trachea. This action does not appear to be related to the cholinergic, adrenergic, or oplate receptors.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1164/arrd.1985.131.1.86 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Standardised activities in wheelchair rugby, comparison between athletes with coordination impairment and athletes with other impairments.
Front Sports Act Living
January 2025
Peter Harrison Centre for Disability Sport, School of Sport, Exercise, and Health Sciences, Loughborough University, Loughborough, United Kingdom.
Introduction: To determine if athletes with coordination impairment (CI) can continue playing wheelchair rugby (WR), while an evidence-based classification system, including impairment tests for CI is not yet available. This is a defensible practise if they show similar activity limitations as athletes with other eligible impairment types (OI) within the same sports class.
Methods: Standardised activities were measured in 58 elite WR athletes; 14 with CI and 44 with OI.
There has been an increasing need for small, low-cost, and low-power consumption optical transceivers for short-reach fiber links. Waveguide-integrated photodetectors (PDs) with wide bandwidth and high responsivity on Si photonics platforms are an essential element for these applications. We have fabricated an O-band membrane PD which is suitable for integration with high-performance III-V-based membrane devices such as lasers and modulators, and passive waveguide circuits on the Si photonics platforms.
View Article and Find Full Text PDFLight trapping structures can enhance the absorption and reduce the thickness and costs of solar cells. Among light trapping structures, the metasurface structure utilizes Mie scattering to make light enter the solar active layer better, thus improving the photovoltaic conversion efficiency of solar cells. Herein, we simulated and optimized a metasurface light-trapping structure for solar cells and implemented this structure on solar cells.
View Article and Find Full Text PDFRe-locative guided search optimized self-sparse attention enabled deep learning decoder for quantum error correction.
Sci Rep
January 2025
Department of Mathematics, School of Advanced Sciences, VIT-AP University, Besides AP Secretariate, Amaravati, Andhra Pradesh, 522237, India.
Heavy hexagonal coding is a type of quantum error-correcting coding in which the edges and vertices of a low-degree graph are assigned auxiliary and physical qubits. While many topological code decoders have been presented, it is still difficult to construct the optimal decoder due to leakage errors and qubit collision. Therefore, this research proposes a Re-locative Guided Search optimized self-sparse attention-enabled convolutional Neural Network with Long Short-Term Memory (RlGS2-DCNTM) for performing effective error correction in quantum codes.
View Article and Find Full Text PDFUV-Resistant Nanostructured Anti-reflective Film for Achieving Efficiency Enhancement of Perovskite Solar Cells and Potential of Fabricating Large-Scale Cu(In, Ga)Se Solar Cells.
ACS Appl Mater Interfaces
January 2025
Guangxi Key Laboratory of Optical and Electronic Material and Devices, School of Materials Science and Engineering, Guilin University of Technology, 12 Jiangan Road, Guilin, Guangxi 541004, China.
Sticker-type transparent antireflective film (STAF) is applied to perovskite solar cells (PSCs) to reduce the reflection and improve the light-trapping ability of PSCs. However, the development of STAF is hindered by many factors, such as expensive materials, low actual service life, unsatisfactory antireflective effect, and a lack of research on stability. This work proposes an ultraviolet (UV)-resistant enhanced sticker-type nanostructure acrylic resin antireflective film (SNAAF), which is applied to the incident surface of PSCs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!