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The Relationship of Fetuin-A with Coronary Calcification, Carotid Atherosclerosis, and Mortality Risk in Non-Dialysis Chronic Kidney Disease.
J Lipid Atheroscler
May 2024
Department of Radiology, Faculty of Medicine, Minia University, Minya, Egypt.
Objective: This study investigated the relationship of fetuin-A with coronary calcification, carotid atherosclerosis, and mortality risk in non-dialysis chronic kidney disease (CKD).
Methods: The study included 135 adult patients with CKD at stages 3-5, who were divided into coronary artery calcification (CAC) and non-CAC groups. We excluded current smokers and individuals with diabetes mellitus, inflammatory conditions, liver diseases, acute kidney failure, chronic hemodialysis, and cancer.
Urinary Post-Translationally Modified Fetuin-A (uPTM-FetA) in Chronic Kidney Disease Patients with and without Diabetic Kidney Disease.
Medicina (Kaunas)
February 2024
Nephrology and Dialysis Unit, Magna Graecia University Hospital, 88100 Catanzaro, Italy.
A novel post-translational modification (PTM) fragment derived from the cleavage of Fetuin-A (PTM-FetA) has recently emerged as a sensitive biomarker for kidney damage in diabetic patients, but evidence in other chronic renal diseases is lacking. In this pilot study, we aimed at evaluating the clinical significance of urinary PTM-FetA (uPTM-FetA) in a mixed cohort of patients with non-advanced chronic kidney disease (CKD) secondary to diabetic kidney disease (DKD) or other causes. We enrolled 47 adult patients with CKD (mean CKD-Epi 40.
View Article and Find Full Text PDFDifferential associations of fetuin-A and calcification propensity with cardiovascular events and subsequent mortality in patients undergoing hemodialysis.
Clin Kidney J
March 2024
Department of Nephrology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Background: Fetuin-A inhibits precipitation of calcium-phosphate crystals by forming calciprotein particles (CPP). A novel T50 test, which measures transformation time from primary to secondary CPP, is an index for calcification propensity. Both lower fetuin-A and shorter T50 levels were associated with cardiovascular disease (CVD) risk in patients with chronic kidney disease (CKD).
View Article and Find Full Text PDFPlasma proteome analysis and validation of patients with community-acquired pneumonia: A cohort study.
Proteomics Clin Appl
July 2024
Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.
Purpose: This study aimed to investigate the diagnostic potential of plasma biomarkers of community-acquired pneumonia (CAP) and their severity grading.
Experimental Design: Plasma proteomes from cohort I (n = 32) with CAP were analyzed by data-independent acquisition mass spectrometry (MS). MetaboAnalyst 5.
Impact of essential metals on insulin sensitivity and fetuin in obesity-related type 2 diabetes pathogenesis.
J Diabetes Metab Disord
June 2023
Department of General Medicine, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.
Article Synopsis
- This study investigates the role of essential metals in obesity and type 2 diabetes (T2DM) by comparing metal levels and fetuin-A (Fet-A) among different groups: diabetic obese, diabetic non-obese, non-diabetic obese, and non-diabetic non-obese subjects.
- Results show that Fet-A levels are significantly higher in T2DM patients and differ notably between the various groups, correlating positively with insulin resistance and negatively with insulin sensitivity.
- Metal levels, particularly copper, selenium, zinc, and iron, were found to be lower in diabetic patients and also show significant correlations with Fet-A and insulin metrics, indicating their potential importance in the diabesity-related pathology.
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