AI Article Synopsis
- The traditional Watson-Crick base pairs in DNA can sometimes shift to a Hoogsteen conformation, which alters the hydrogen bond structure.
- Previous studies have indicated that the Hoogsteen form is common in alternating adenine-thymine (AT) sequences, but new research shows that it can also occur in other all-AT sequences like d(ATTAAT)2.
- The study concludes that any all-AT DNA sequence may adopt the Hoogsteen conformation under suitable conditions and highlights the differences between the two conformations.
Article Abstract
The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is favored in alternating AT sequences of DNA. Here we present new data for a different sequence, d(ATTAAT)2, which is also found in the Hoogsteen conformation. Thus we demonstrate that other all-AT sequences of DNA with a different sequence may be found in the Hoogsteen conformation. We conclude that any all-AT sequence might acquire this conformation under appropriate conditions. We also compare the detailed features of DNA in either the Hoogsteen or Watson-Crick conformations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363561 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120241 | PLOS |
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