This study reports the optical characterization and quantitative oximetry of human breast cancer using spectrally-resolved images collected with a broadband, continuous-wave optical mammography instrument. On twenty-six cancer patients, we collected two-dimensional optical mammograms and created maps of the concentrations of hemoglobin, water, and lipids, as well as the oxygen saturation of hemoglobin. For each cancerous breast, we analyzed the difference between the tumor region (as identified by x-ray and optical mammography) and the remainder of breast tissue. With respect to the surrounding tissue, we found that cancer regions have significantly higher concentrations of total hemoglobin (+2.4 ± 0.4 μM) and water (+7 ± 1% v/v), and significantly lower lipid concentration (8 ± 2% v/v) and oxygen saturation of hemoglobin (5 ± 1%). We also found a significant correlation between the tumor optical contrast and the grade of breast cancer as quantified by the Nottingham histologic score; this demonstrates how optical signatures may be representative of metabolic and morphological features, as well as the aggressive potential of the tumor.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363570 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117322 | PLOS |
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Diversity, inclusivity and traceability of mammography datasets used in development of Artificial Intelligence technologies: a systematic review.
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Article Synopsis
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View Article and Find Full Text PDFEnhancing Radiologist Reading Performance by Ordering Screening Mammograms Based on Characteristics That Promote Visual Adaptation.
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From the Departments of Medical Imaging (J.J.J.G., S.D.V., I.S.) and IQ Health (M.J.M.B.), Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, the Netherlands (K.M.D.); Department of Radiology and Nuclear Medicine, Haga Teaching Hospital, Den Haag, the Netherlands (J.K.v.R.); Department of Radiology, Gelre Hospitals, Apeldoorn, the Netherlands (A.F.v.R.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, the Netherlands (J.B.H.); Department of Radiology, Diakonessenhuis, Utrecht, the Netherlands (D.B.N.); Department of Radiology, Canisius Wilhelmina Hospital, Nijmegen, the Netherlands (L.E.M.D.); Department of Psychological and Brain Sciences, University of California Santa Barbara, Santa Barbara, Calif (C.K.A.); Department of Psychology, University of Nevada, Reno, Nev (M.A.W.); Dutch Expert Centre for Screening, Nijmegen, the Netherlands (M.J.M.B., I.S.); and Technical Medicine Center, University of Twente, Enschede, the Netherlands (I.S.).
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JAAPA
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Extremely dense breasts can be an independent risk factor for breast cancer. A new FDA rule requires that patients be notified of their breast density and the possible benefits of additional imaging to screen for breast cancer. Clinicians should be cognizant of the data about breast cancer risk, breast density, and recommendations to change screening techniques if patients, particularly premenopausal females, have extremely dense breasts but no other known risk factors.
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