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Unlabelled: Transparent and accurate reporting in early phase dose-finding (EPDF) clinical trials is crucial for informing subsequent larger trials. The SPIRIT statement, designed for trial protocol content, does not adequately cover the distinctive features of EPDF trials. Recent findings indicate that the protocol contents in past EPDF trials frequently lacked completeness and clarity.
View Article and Find Full Text PDFAging and word predictability during reading: Evidence from eye movements and fixation-related potentials.
Atten Percept Psychophys
January 2025
School of Psychology and Vision Sciences, George Davies Centre for Medicine, University of Leicester, University Road, Leicester, LE1 7RH, UK.
The use of context to facilitate the processing of words is recognized as a hallmark of skilled reading. This capability is also hypothesized to change with older age because of cognitive changes across the lifespan. However, research investigating this issue using eye movements or event-related potentials (ERPs) has produced conflicting findings.
View Article and Find Full Text PDFEXPLORATORY STRUCTURAL NEUROIMAGING EXAMINATION OF IMPULSIVITY IN SEVERE ALCOHOL USE DISORDER: PERSISTENT IMPLICATION OF THE VENTRAL STRIATUM.
Behav Brain Res
January 2025
Normandie Univ, UNICAEN, INSERM, PhIND "Physiopathology and Imaging of Neurological Disorders", Cyceron, 14000 Caen, France; Institut Universitaire de France (IUF).
Background: While Alcohol Use Disorder (AUD) is frequently associated with impulsivity, its structural brain substrates are still poorly defined. The triadic model of addiction postulates that impulsive behavior is regulated by an amygdalo-striatal impulsive subcomponent, a prefrontal and cerebellar reflective subcomponent, and an insular regulatory subcomponent. The objective of this study was thus to examine the relationships between self-evaluated impulsivity and structural brain abnormalities in patients with severe AUD (sAUD) using the triadic model as a theoretical framework.
View Article and Find Full Text PDFRacism and the well-being of nurses of color: A scoping review.
Nurs Outlook
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Sue & Bill Gross School of Nursing, University of California Irvine, Irvine, CA; Department of Psychological Science, University of California Irvine, Irvine, CA. Electronic address:
Background: Structural disparities in the United States (U.S.) healthcare system negatively impact care access and quality for racial and ethnic minorities.
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