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Background: Neurodevelopmental origins of functional variation through the lifespan are acknowledged, but pathways need to be identified. The objectives of the project Set-to-change is to test whether and how early life environmental factors and genetic makeup regulate brain and cognition and its change, as well as neurocognitive plasticity in response to training through the lifespan.
Method: Preliminary analyses for the first months are presented.
Biomarkers.
Alzheimers Dement
December 2024
Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
Background: Accumulation of amyloid beta in the brain is one of the first events in Alzheimer's disease (AD) and starts decades before symptoms arise. It has been hypothesized that brain areas with higher levels of neuronal activation ('hubs') are more prone to amyloid deposition. In this study, we examined the regional relationship between cortical hubs and longitudinal changes in amyloid pathology in a sample of cognitively healthy older subjects.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
Centre for Healthy Brain Ageing (CHeBA), University of New South Wales, UNSW Sydney, NSW, Australia.
Background: Social connections are associated with brain health, but the extent to which social connections are heritable remains unclear. Using longitudinal twin data, we explored the heritable and environmental contributions to social connections. We hypothesised that social connections patterns would be moderately heritable and would be associated with better cognitive and mental health over time.
View Article and Find Full Text PDFDemarcation of anxiety and fear: Evidence from behavioral genetics.
J Affect Disord
December 2024
Department of Psychology, City St George, University of London, London, United Kingdom. Electronic address:
Anxiety and fear are emotions often intertwined in response to aversive stimuli, complicating efforts to differentiate them and understand their distinct consequences. This study explores the common genetic and environmental factors contributing to the co-occurrence of anxiety disorders and dimensions of the revised Reinforcement Sensitivity Theory (rRST). A sample of 356 monozygotic (22.
View Article and Find Full Text PDFDIVERGENT PRESENTATION OF GRIN2B NEURODEVELOPMENTAL DISORDER IN MONOZYGOTIC TWINS: CASE REPORT WITH UNIQUE IMAGING PHENOTYPES.
Neuropediatrics
December 2024
Great Ormond Street Hospital for Children, London, United Kingdom of Great Britain and Northern Ireland.
We describe a set of monozygotic twins with GRIN2B-related neurodevelopmental disorder (GRIN2B-ND) who exhibited distinct clinical and imaging characteristics due to a de novo heterozygous pathogenic variant in the GRIN2B gene (c.2453T>C, p.Met818Thr).
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