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A topographic approach to the markers of macrophage/ microglia and other cell types in high grade glioma.
Neurochem Int
December 2024
Department of Neurosurgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy. Electronic address:
In glioblastoma, glioma-associated microglia/macrophages (GAMs) represent the major population of tumor infiltrating cells, with up to one half of the cells of the tumor mass. Recent studies have shown that microglia are involved in the maintenance of immunological homeostasis and protection against autoimmunity. However, despite the growing body of evidence on the topic, many aspects are yet to be clarified.
View Article and Find Full Text PDFThe effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology.
Neurobiol Dis
December 2024
Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia. Electronic address:
Amino acid substitutions in the kinase domain of the human CSF1R protein are associated with autosomal dominant adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). To model the human disease, we created a disease-associated mutation (Glu631Lys; E631K) in the mouse Csf1r locus. Previous analysis demonstrated that heterozygous mutation (Csf1r) had a dominant inhibitory effect on CSF1R signaling in vitro and in vivo but did not recapitulate human disease pathology.
View Article and Find Full Text PDFArticle Synopsis
- - Microglia play a key role in regulating cerebral blood flow (CBF), particularly during activities like whisker stimulation or ATP injection, affecting both baseline levels and increases in blood flow.
- - Depleting microglia reduces activity-dependent blood flow responses, but the body still responds normally to other stimuli like adenosine, indicating a specific function for microglia in this process.
- - The regulation of CBF by microglia involves the ATP-sensing receptor P2ry12 and the enzyme CD39, which converts extracellular ATP into adenosine, crucial for neurovascular coupling and maintaining healthy blood flow responses.
Effect of Calcium Channel Blockers on Antiplatelet Activity of Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention: Insights from the PTRG-DES Consortium.
J Cardiovasc Pharmacol Ther
November 2024
Department of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, South Korea.
Calcium channel blockers (CCBs) are frequently co-administered with clopidogrel in cardiovascular disease. Although an inhibitory drug interaction exists between them, comprehensive large-scale studies for its validation are lacking. We investigated interactions between CCBs and clopidogrel using a large-scale national registry of patients who underwent percutaneous coronary intervention (PCI).
View Article and Find Full Text PDFNeuroinflammation in comorbid depression in Alzheimer's disease: A pilot study using post-mortem brain tissue.
Neurosci Appl
January 2024
Dementia Research Group, University of Bristol, Bristol, UK.
Comorbid depression and Alzheimer's disease (AD) is associated with poorer prognosis than either condition alone. Neuroinflammation has been implicated in the pathogenesis and progression of both depression and AD, but much of the existing research has been based on peripheral blood immune markers. Relatively little is known about the neuroinflammatory environment when these conditions occur simultaneously and using immune measures directly in the brain tissue.
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