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Fullerene and fullerene whisker are not carcinogenic to the lungs and pleura in rat long-term study after 2-week intra-tracheal intrapulmonary administration.
Arch Toxicol
December 2024
Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
Article Synopsis
- - Fullerene whiskers (FLWs) and fullerenes (FLs) are rod-like structures made of carbon, and their shape raises concerns about potential health risks similar to those posed by asbestos and carbon nanotubes, but no long-term studies on their carcinogenic effects have been conducted.
- - In a study, male rats were given FL, FLW, and different types of multi-walled carbon nanotubes (MWCNT) to assess lung and pleural carcinogenicity, leading to analyses at 1 and 104 weeks post-exposure.
- - Results showed that while MWCNT exposure led to significant increases in lung tumors and oxidative DNA damage, FL and FLW did not induce carcinogenic effects in the
Subchronic particulate matter exposure underlying polyhexamethylene guanidine phosphate-induced lung injury: Quantitative and qualitative evaluation with chest computed tomography.
Heliyon
July 2024
Department of Pathology, Ansan Hospital, Korea University College of Medicine, 123, Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi, 15355, South Korea.
Article Synopsis
- The study focused on how long-term exposure to particulate matter (PM) affects lung damage caused by a chemical called polyhexamethylene guanidine phosphate (PHMG-p) in rats.
- Researchers treated rats with PHMG-p, then exposed one group to PM and compared their lung health to a control group given saline over 10 weeks.
- Results showed significant increases in lung inflammation and fibrosis in the PM group, indicating that PM exposure worsened lung injury linked to PHMG-p.
Lung carcinogenicity by whole body inhalation exposure to Anatase-type Nano-titanium Dioxide in rats.
J Toxicol Sci
August 2024
Japan Bioassay Research Center (JBRC), Japan Organization of Occupational Health and Safety.
Article Synopsis
- A study on the carcinogenicity of anatase-type nano-titanium dioxide (aNTiO) involved exposing F344/DuCrlCrlj rats to different aerosol concentrations for two years.
- The results showed that while bronchiolo-alveolar carcinomas appeared in two males exposed to the highest concentration, this finding was not significantly higher than historical control data.
- Non-cancerous lung lesions were noted, and the aNTiO levels in the lungs of rats decreased over time after exposure, leading to the conclusion of equivocal evidence for aNTiO's carcinogenicity.
Chronic Inhalation Exposure to Antimony Trioxide Exacerbates the MAPK Signaling in Alveolar Bronchiolar Carcinomas in B6C3F1/N Mice.
Toxicol Pathol
January 2023
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
Antimony trioxide (AT) is used as a flame retardant in fabrics and plastics. Occupational exposure in miners and smelters is mainly through inhalation and dermal contact. Chronic inhalation exposure to AT particulates in B6C3F1/N mice and Wistar Han rats resulted in increased incidences and tumor multiplicities of alveolar/bronchiolar carcinomas (ABCs).
View Article and Find Full Text PDFClinicopathologic Features and Frozen Diagnostic Pitfalls of Bronchiolar Adenoma/Ciliated Muconodular Papillary Tumors (BA/CMPTs).
Am J Surg Pathol
April 2023
Department of Pathology, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
To describe the histologic features of bronchiolar adenoma/ciliated muconodular papillary tumors (BA/CMPTs) and analyze the pitfalls in diagnosis from frozen sections. A total of 208 frozen and permanent sections of BA/CMPTs from Shanghai Chest Hospital from July 2018 to July 2021 were retrospectively analyzed. The median age of BA/CMPT patients was 65 years (15 to 79 y), and women accounted for 61.
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