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Impact of pharmacological interventions on intrapulmonary shunt during one-lung ventilation in adult thoracic surgery: a systematic review and component network meta-analysis.
Br J Anaesth
January 2023
Department of Acute Medicine, Geneva University Hospitals, Geneva, Switzerland.
Background: Intrapulmonary shunt is a major determinant of oxygenation in thoracic surgery under one-lung ventilation. We reviewed the effects of available treatments on shunt, Pao/FiO and haemodynamics through systematic review and network meta-analysis.
Methods: Online databases were searched for RCTs comparing pharmacological interventions and intrapulmonary shunt in thoracic surgery under one-lung ventilation up to March 30, 2022.
Vasoactive agents in acute mesenteric ischaemia in critical care. A systematic review.
F1000Res
November 2021
NHS Grampian, Aberdeen, UK.
: Acute mesenteric ischaemia (AMI) is a surgical emergency which has an associated high mortality. The mainstay of active treatment includes early surgical intervention, with resection of non-viable bowel, and revascularisation of the ischaemic bowel where possible. Due to the physiological insult of AMI however, perioperative care often involves critical care and the use of vasoactive agents to optimise end organ perfusion.
View Article and Find Full Text PDFHepatic Arterial Buffer Response in Liver Radioembolization and Potential Use for Improved Cancer Therapy.
Cancers (Basel)
March 2021
Nuclear Medicine Department, Cliniques Universitaires Saint-Luc, 1200 Brussels, Belgium.
Liver radioembolization is a treatment option for unresectable liver cancers, performed by infusion of Y or Ho loaded spheres in the hepatic artery. As tumoral cells are mainly perfused via the liver artery unlike hepatic lobules, a twofold tumor to normal liver dose ratio is commonly obtained. To improve tumoral cell killing while preserving lobules, co-infusion of arterial vasoconstrictor has been proposed but with limited success: the hepatic arterial buffer response (HABR) and hepatic vascular escape mechanism hamper the arterioles vasoconstriction.
View Article and Find Full Text PDFRetraction: Boldt J, Papsdorf M, Piper S, Padberg W, Hempelmann G. Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery. Acta Anaesthesiol Scand. 1998;42(8):941-7. https://doi.org/10.1111/j.1399-6576.1998.tb05354.x.
Acta Anaesthesiol Scand
April 2021
Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome.
Cochrane Database Syst Rev
November 2020
Department of Anaesthesiology and Surgical Intensive Care, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany.
Background: Cardiogenic shock (CS) and low cardiac output syndrome (LCOS) are potentially life-threatening complications of acute myocardial infarction (AMI), heart failure (HF) or cardiac surgery. While there is solid evidence for the treatment of other cardiovascular diseases of acute onset, treatment strategies in haemodynamic instability due to CS and LCOS remains less robustly supported by the given scientific literature. Therefore, we have analysed the current body of evidence for the treatment of CS or LCOS with inotropic and/or vasodilating agents.
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