AI Article Synopsis
- The MCFphone is a new portable detection system designed for quick and precise measurements of prostate specific antigen (PSA) using colorimetric and fluorescence immunoassays.
- It features a smartphone, a magnifying lens, a simple light source, and a Microcapillary Film (MCF) platform, allowing PSA quantification from 0.9 to 60 ng/ml in just 13 minutes with high precision.
- The system has improved sensitivity to detect PSA as low as 0.08 ng/ml in whole blood, marking an advancement in affordable and portable diagnostic tools that leverage existing smartphone technology.
Article Abstract
We present a new, power-free and flexible detection system named MCFphone for portable colorimetric and fluorescence quantitative sandwich immunoassay detection of prostate specific antigen (PSA). The MCFphone is composed by a smartphone integrated with a magnifying lens, a simple light source and a miniaturised immunoassay platform, the Microcapillary Film (MCF). The excellent transparency and flat geometry of fluoropolymer MCF allowed quantitation of PSA in the range 0.9 to 60 ng/ml with<7% precision in 13 min using enzymatic amplification and a chromogenic substrate. The lower limit of detection was further improved from 0.4 to 0.08 ng/ml in whole blood samples with the use of a fluorescence substrate. The MCFphone has shown capable of performing rapid (13 to 22 min total assay time) colorimetric quantitative and highly sensitive fluorescence tests with good %Recovery, which represents a major step in the integration of a new generation of inexpensive and portable microfluidic devices with commercial immunoassay reagents and off-the-shelf smartphone technology.
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| http://dx.doi.org/10.1016/j.bios.2015.03.006 | DOI Listing |
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