AI Article Synopsis
- Early lymphocyte recovery is crucial for preventing infections and eliminating leftover tumor cells after allogeneic hematopoietic stem cell transplantation (HSCT).
- Researchers studied lymphocyte counts on days 20 and 30 post-transplant in 100 patients with blood cancers to assess outcomes like survival and infection risks.
- Findings showed that patients with low lymphocyte counts (<300 × 10^3/μL) on day 30 faced a 3.76 times higher risk of death within 100 days, indicating that slower lymphocyte recovery can predict early mortality after HSCT.
Article Abstract
Introduction: Early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation (HSCT) is related to the prevention of serious infections and the clearing of residual tumor cells.
Methods: We analyzed the absolute lymphocyte count at 20 (D+20) and 30 (D+30) days after HSCT in 100 patients with malignant hematologic diseases and correlated with the risk of transplant-related mortality, overall survival (OS), disease-free survival (DFS), nonrelapsed mortality (NRM), and risk of infection.
Results: Patients presenting with lymphocyte counts of <300 × 103/μL on D+30 have a 3.76 times greater risk of death in <100 days. Over a medium follow-up of 20 months OS, DFS, and NRM were similar between the groups.
Conclusion: In our group of patients delayed lymphocyte recovery after HSCT was a predictor of early death post-HSCT.
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| http://dx.doi.org/10.1016/j.transproceed.2014.11.042 | DOI Listing |
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