Background: Enchondromas are benign cartilaginous tumours. The most common location is in the long bones of the hand. Treatment methods fall into a broad spectrum ranging from conservative, medical therapies, to a variety of surgical procedures, which may or may not employ the use of local adjuvant treatment or bone grafting. The purpose of this study was to report our experience and evaluate the long-term results of patients with enchondroma of the hand, treated in our department with meticulous curettage, phenolization and coralline hydroxyapatite grafting.
Methods: We present 82 patients with hand enchondromas treated surgically in our department during the last 10 years. The patients were treated operatively with meticulous curettage of the bone lesion, with use of phenol 5 % as local adjuvant and coralline hydroxyapatite bone graft to fill in the remaining cavity.
Results: At a minimum of 5-year follow-up, radiographs and clinical examination showed adequate bone formation at the site of enchondroma excavation and no evidence of recurrence, fracture, infection or other complication related to the procedure.
Conclusion: We concluded that the combination of meticulous curettage of the lesion, with the use of phenol as local adjuvant and coralline hydroxyapatite graft is a safe technique that prevents recurrence and allows adequate and uncomplicated local new bone formation.
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http://dx.doi.org/10.1007/s11552-014-9674-2 | DOI Listing |
Biomater Adv
February 2022
Department of Stomatology, The Fifth Medical Center, Chinese PLA General Hospital, Xisihuan Middle Road 100, Fengtai District, Beijing 100036, PR China. Electronic address:
The multi-bacterial environment of the oral cavity makes it hard for periodontal regeneration. As a class of antimicrobial peptide, beta defensin has been found to show broad-spectrum antibacterial ability. In addition, connective tissue growth factor (CTGF) is demonstrated to play a great role in multi-physiological events such as angiogenesis, wound healing and, more importantly, fibrogenesis.
View Article and Find Full Text PDFBr J Oral Maxillofac Surg
December 2021
Instituto de Biología y Genética Molecular (IBGM), Centro Superior de Investigaciones Científicas (CSIC), Valladolid, Spain. Electronic address:
The purpose of this paper was to investigate the bone regeneration effect of autologous adipose tissue mesenchymal stem cells (ATMSC) in a small animal model. Twelve Wistar rats were given bilateral critical-size defects in the mandible. The defects were filled with coralline hydroxyapatite alone or combined with autologous undifferentiated ATMSC obtained from the dorsal fat pad.
View Article and Find Full Text PDFOrthop Surg
December 2020
Department of Trauma Orthopaedics, General Hospital of Southern Theater Command, PLA, Guangzhou, China.
Objective: Spinal fusion is one of the most common surgical interventions for spine reconstruction. Despite the efforts to promote osteogenesis after spinal fusion, osteogenesis after spinal fusion remains a clinical challenge and new methods are still needed. The bone morphogenetic protein-2 (BMP-2) is a widely reported factor that can facilitate the osteogenesis in spinal fusion.
View Article and Find Full Text PDFFront Bioeng Biotechnol
September 2020
Graduate School, Jinzhou Medical University, Jinzhou, China.
Background: Fractures are a medical disease with a high incidence, and about 5-10% of patients need bone transplantation to fill the defect. In this study, we aimed to synthesize a new type of coralline hydroxyapatite (CHA)/silk fibroin (SF)/glycol chitosan (GCS)/difunctionalized polyethylene glycol (DF-PEG) self-healing hydrogel and to evaluate the therapeutic effects of this novel self-healing hydrogel as a human umbilical cord mesenchymal stem cells (hucMSC)-derived exosome carrier on bone defects in SD rat.
Methods: HucMSCs were isolated from fetal umbilical cord tissue and characterized by surface antigen analysis and pluripotent differentiation .
J Mech Behav Biomed Mater
April 2020
Institute of Life Science, College of Medicine, Swansea University, UK. Electronic address:
Coralline hydroxyapatite (CHA) has been used in clinical for over 20 years. However, coral is an endanger species and has been banned from mining. In addition, coral artificial bone has slow biodegradation of the defects, hindering the growth of new bone.
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