Objective: To study the NAT2 gene polymorphisms 481T, 590A and 857A in the Chimila, Wiwa and Wayuu indigenous groups of the Colombian Caribbean to determine the frequencies of the alleles NAT2*4, NAT2*5, NAT2*6, and NAT2*7 and to determine the types of acetylators present in these populations.
Methods: A total of 202 subjects were studied: 47 Chimila, 55 Wiwa, and 100 Wayuu. The polymorphisms were identified using a real-time PCR method for allelic discrimination designed using Taqman of Applied Biosystems.
Results: The following alleles were found at the highest frequency in the following groups: the NAT2*4 allele (wild type) in the Wayuu group (55.3%), the NAT2*5 allele in the Wiwa group (34.5%), and the NAT2*7 allele in the Chimila group (24.2%). A higher frequency of the rapid acetylator status was found in the Wayuu group (31.3%) and Chimila group (29.5%) compared with the Wiwa group (12.7%). The intermediate acetylator status distribution was very similar in all three groups, and the frequency of the slow acetylator status was higher in the Wiwa group (32.7%) compared with the Chimila and Wayuu groups (20.5% and 21.2%, respectively).
Conclusion: The results demonstrated the allelic distribution and pharmacogenetic differences of the three groups studied and revealed the most frequent acetylator status and phenotype. Because of the high prevalence of slow acetylators, a greater incidence of tuberculosis (TB) drug-induced hepatotoxicity is predicted in these populations, with a higher frequency in the Wiwa group.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350379 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Navigating vaccine procurement and financing challenges in Cameroon: Insights and recommendations from a mixed-methods study (2015-2020).
Public Health
December 2024
Institute for Global Health, University of Siena, 53100, Siena, Italy; International Vaccines Institute, Seoul, South Korea.
Objectives: Vaccine stockouts at the national level has been recognized as a critical challenge in ensuring sustained and equitable immunization coverage. These stockouts often arise from inherent issues within countries, including delays in government funding, suboptimal forecasting and stock management practices, and inefficiencies in the procurement process amongst others. Understanding the complexities and barriers within vaccine procurement and financing systems is crucial for developing effective strategies to enhance vaccine availability and strengthen immunization programs.
View Article and Find Full Text PDFSeroprevalence of Spp. and in Indigenous Populations from the Sierra Nevada de Santa Marta, Colombia.
Vector Borne Zoonotic Dis
October 2024
Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.
Article Synopsis
- The study focused on the seroprevalence of Rickettsial species in two indigenous communities in Colombia, revealing an overall seroprevalence of 26.2% for Spotted Fever Group (SFG) and lower percentages for Typhus Group (TG) and Scrub Typhus.
- Increased risk of SFG seropositivity was associated with participants involved in livestock care, particularly during farming activities like assisting with births.
- The findings indicate significant exposure to these zoonotic pathogens, suggesting a need for enhanced awareness and research on rickettsial infections in rural Colombia, amidst concerns over serious outcomes like Rocky Mountain Spotted Fever.
Chagas Disease: Comparison of Therapy with Nifurtimox and Benznidazole in Indigenous Communities in Colombia.
J Clin Med
April 2024
Statistical Consulting, 97074 Wuerzburg, Germany.
: For indigenous people in Colombia, high infection rates with Chagas disease (CD) are known. : In 2018 and 2020, nine villages were screened for CD. CD-positive patients could enter a drug observed treatment.
View Article and Find Full Text PDFMining from the pipeline: Artisanal oil refining as a consequence of failed CSR policies in the Niger Delta.
J Environ Manage
February 2024
Research Innovation and Development, Walter Sisulu University, Nelson Mandela Drive, Mthatha, Eastern Cape, South Africa.
Oil production in the Niger Delta first attained global prominence after the 1995 hangings of Ken Saro-Wiwa and eight other Ogonis. In the face of horrible publicity and credible allegations that international oil companies were complicit in systematic human rights violations against local host communities, corporate social responsibility (CSR) was embraced. CSR in the Nigerian oil industry has evolved from non-existent to limited community development programs to today's Global Memorandum of Understanding model.
View Article and Find Full Text PDFBackground: Although anti-SARS-CoV-2 humoral immune responses and epidemiology have been extensively studied, data gaps remain for certain populations such as indigenous people or children especially in low- and middle-income countries. To address this gap, we evaluated SARS-CoV-2 seroprevalence and humoral immunity towards the parental B.1 strain, local SARS-CoV-2 variants, and endemic coronaviruses in children from Colombia from March to April 2021.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!