The place of histamine among primary mediators in allergic rhinitis and the mechanism of action of antihistamines have been discussed. The use of Loderix was tried in 40 chronic rhinitis patients by the open method. According to the observations the second generation Loderix may be successfully used in allergic rhinitis and "eosinophil" type vasomotor rhinitis cases. The side-effects of Loderix did not differ from those of the other antihistamine products.
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