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Finite element analysis of the plantar support for the medial longitudinal arch with flexible flatfoot.
PLoS One
January 2025
Department of Orthopedics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.
Purpose: The present study is to explore the appropriate plantar support force for its effect on improving the collapse of the medial longitudinal arch with flexible flatfoot.
Methods: A finite element model with the plantar fascia attenuation was constructed simulating as flexible flatfoot. The appropriate plantar support force was evaluated.
Clinical Manifestations.
Alzheimers Dement
December 2024
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Background: Prior longitudinal studies among older adults have documented associations between hearing loss and changes in brain morphology. Whether interventions involving hearing aids can reduce age-related atrophy is unknown. A substudy within the Aging and Cognitive Health Evaluation in Elders (ACHIEVE, Clinicaltrials.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of Melbourne, Parkville, VIC, Australia.
Article Synopsis
- Alzheimer's disease (AD) progression varies significantly, and a machine learning model was developed to differentiate between individuals with mild cognitive impairment (MCI) who progress to AD and those who do not, while also predicting their cognitive scores after 3 years.
- The study utilized data from 2,428 participants in the AIBL study, employing various machine learning techniques—specifically support vector machines (SVM), gradient boosting (GB), and random forests (RF)—and determined the RF model provided the highest accuracy and predictive performance.
- The RF-stack model not only excelled in classifying MCI progressors with an area under the receiver operating characteristic curve of 0.85 but also demonstrated the lowest mean average error in
Fascicle differentiation of upper extremity nerves on high-resolution ultrasound with multimodal microscopic verification.
Sci Rep
January 2025
Department of Radiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
This study aimed to compare the fascicular anatomy of upper limb nerves visualized using in situ high-resolution ultrasound (HRUS) with ex vivo imaging modalities, namely, magnetic resonance microscopy (MRM), histological cross-sections (HCS), and optical projection tomography (OPT). The median, ulnar, and superficial branch of radial nerve (n = 41) were visualized in 14 cadaveric upper limbs using 22-MHz HRUS. Subsequently, the nerves were excised, imaged with different microscopic techniques, and their morphometric properties were compared.
View Article and Find Full Text PDFDelineation of the Genetic Architecture and Clinical Polymorphism of 3q29 Duplication Syndrome: A Review of the Literature and a Report of Two Novel Patients With Single-Gene BDH1 Duplications.
Mol Genet Genomic Med
January 2025
Laboratory of Ontogenetics, Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
Background: Chromosome 3q29 duplication syndrome is a rare chromosomal disorder with a frequency of 1:5000 in patients with a neurodevelopmental phenotype. The syndrome is characterized by phenotypic polymorphism and reduced penetrance.
Methods: Patients were investigated by performing a cytogenetic analysis of GTG-banded metaphases, aCGH with the SurePrint G3 Human CGH Microarray 8×60K, qPCR, FISH, and WES.
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