[Tubulointerstitial changes in patients with a history of hemorrhagic fever with renal syndrome].

Altogether 85 patients with a history of hemorrhagic fever and the nephrotic syndrome (HFNS) were examined at different stages after the disease, characterizing the status of the tubulointerstitial apparatus of the kidneys. Almost half of the patients who suffered this disease manifested a decrease in the capacity of the kidneys for osmotic concentration of urine under the conditions of deprivation for 36 hours, and in acid-secretory function of the kidneys under induced acidosis and clearance of uric acid. Ultrasonic studies demonstrated that part of the patients had uni- or bilateral indurations in the renal parenchyma. In 16% of the examined, these alterations may be related to superaddition of pyelonephritis after HFNS. The nature of tubulointerstitial lesions remains unknown in other cases and thus requires a further study. The recovery of tubular functions of the kidneys following HFNS continues for 3 years. In view of this fact patients with a history of this disease need prolonged follow-up.