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The literature and own data on the efferent innervation of cerebral vessels, its sources and the structure of neurogenic regulation of intracranial hemodynamics, are summed up. Diverse mechanisms of the cerebral vessels' innervation involve polymodal efferent fibers and terminals associated with existence of numerous transmitters, the participation of some bulbar nuclei along with the sympathetic system in the innervation. The diversity of the controlling factors seems to be the result of an imperfection of cerebral blood supply system due to its accelerated development in the course of phylogenesis.
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