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Toxicodynamic insights of 2C and NBOMe drugs - Is there abuse potential?
Toxicol Rep
June 2025
Associate Laboratory i4HB-Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Drug use represents a prevalent and multifaceted societal problem, with profound implications for public health, social welfare, and economic stability. To circumvent strict international drug control regulations, there is a growing trend in the development and market introduction of novel psychoactive substances (NPS), encompassing a wide range of compounds with psychoactive properties. This includes, among other classes of drugs, the phenethylamines.
View Article and Find Full Text PDFAreas of modernization of the system of training and certification of forensic experts in Ukraine based on the adaptation of foreign experience.
Forensic Sci Res
December 2024
Department of Political Science and Law, Kyiv National University of Construction and Architecture, Kyiv, Ukraine.
Unlabelled: The article is devoted to the study of the existing system of training and certification of forensic experts in Ukraine and to the provision of proposals for its modernization, taking into account the positive experience in the field of forensic science of the USA, UK and some countries of the European Union. In Ukraine, the procedure for the training and certification of forensic experts is determined by ministries and other central executive authorities, which manage state specialized institutions that carry out forensic activities. A study of foreign experience in the training and certification of forensic experts made it possible to identify general and specific elements, sustain the benefits of the implemented measures, and formulate priorities and guidelines.
View Article and Find Full Text PDFIntegrating the GRACE Score with the Ceramide Risk Score Enhances the Predictive Accuracy of Major Adverse Cardiac Events in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.
Rev Cardiovasc Med
January 2025
Department of Cardiology, Renmin Hospital of Wuhan University, 430060 Wuhan, Hubei, China.
Background: Ceramide, a key molecule in sphingolipid metabolism, is recognized as a standalone predictor of long-term major adverse cardiac events (MACE). We explore if integrating the global registry of acute coronary events (GRACE) score with the ceramide risk score (ceramide test 1, CERT1) improves MACE prediction in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).
Methods: This cohort study included 210 participants with ACS undergoing PCI.
Proposing a two-stage screening approach to distinguish between transient and enduring postnatal depressive symptoms: A prospective cohort study.
Int J Nurs Stud Adv
June 2025
Centre of Excellence in Early Intervention and Family Studies, Department of Psychology, University of Copenhagen, Denmark.
Background: Screening for perinatal depression using the Edinburgh Postnatal Depression Scale (EPDS) improves detection and increases health service utilization. However, previous studies with antenatal samples indicate that positive screenings might reflect transient distress that resolves without intervention, raising concerns about over-pathologizing typical postnatal responses and inefficiencies in referral practices. Therefore, distinguishing between transient and enduring depressive symptoms for appropriate referrals to secondary services is crucial, highlighting the need for a refined screening practice.
View Article and Find Full Text PDFAnisotropy of the Orientation Selectivity in the Visual Cortex Area 18 of Cats Reared Under Normal and Altered Visual Experience.
Eur J Neurosci
January 2025
Pavlov Institute of Physiology RAS, Saint-Petersburg, Russia.
The "oblique effect" refers to the reduced visual performance for stimuli presented at oblique orientations compared to those at cardinal orientations. In the cortex, neurons that respond to specific orientations are organized into orientation columns. This raises the question: Are the orientation signals in the iso-orientation columns associated with cardinal orientations the same as those in the iso-orientation columns associated with oblique orientations, and is this signal influenced by experience? To explore this, iso-orientation columns in visual area 18 were examined using optical imaging techniques.
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