AI Article Synopsis
- A study was conducted to compare the effectiveness of minimum-dose (MS) versus high-dose (HS) stimulation protocols in improving clinical pregnancy rates for women with poor ovarian reserve (POR) undergoing IVF.
- The MS protocol involved lower doses of medications (letrozole and gonadotropins) and yielded significantly higher clinical pregnancy and live birth rates compared to the HS protocol, which used larger doses of gonadotropins.
- The findings suggest that the MS protocol is not only more effective but also more cost-efficient for treating patients with poor ovarian reserve.
Article Abstract
We examined whether treatment with minimum-dose stimulation (MS) protocol enhances clinical pregnancy rates compared to high-dose stimulation (HS) protocol. A retrospective cohort study was performed comparing IVF and pregnancy outcomes between MS and HS gonadotropin-antagonist protocol for patients with poor ovarian reserve (POR). Inclusion criteria included patients with an anti-Müllerian hormone (AMH) ≤8 pmol/L and/or antral follicle count (AFC) ≤5 on days 2-3 of the cycle. Patients from 2008 exclusively had a HS protocol treatment, while patients in 2010 had treatment with a MS protocol exclusively. The MS protocol involved letrozole at 2.5 mg over 5 days, starting from day 2, overlapping with gonadotropins, starting from the third day of letrozole at 150 units daily. GnRH antagonist was introduced once one or more follicles reached 14 mm or larger. The HS group received gonadotropins (≥300 IU/day) throughout their antagonist cycle. Clinical pregnancy rate was significantly higher in the MS protocol compared to the HS protocol (P = 0.007). Furthermore, the live birth rate was significantly higher in the MS group compare to the HS group (P = 0.034). In conclusion, the MS IVF protocol is less expensive (lower gonadotropin dosage) and resulted in a higher clinical pregnancy rate and live birth rate than a HS protocol for poor responders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334044 | PMC |
| http://dx.doi.org/10.1155/2014/581451 | DOI Listing |
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