Parametric amplification, resulting from intentionally varying a parameter in a resonator at twice its resonant frequency, has been successfully employed to increase the sensitivity of many micro- and nano-scale sensors. Here, we introduce the concept of self-induced parametric amplification, which arises naturally from nonlinear elastic coupling between the degenerate vibration modes in a micromechanical disk-resonator, and is not externally applied. The device functions as a gyroscope wherein angular rotation is detected from Coriolis coupling of elastic vibration energy from a driven vibration mode into a second degenerate sensing mode. While nonlinear elasticity in silicon resonators is extremely weak, in this high quality-factor device, ppm-level nonlinear elastic effects result in an order-of-magnitude increase in the observed sensitivity to Coriolis force relative to linear theory. Perfect degeneracy of the primary and secondary vibration modes is achieved through electrostatic frequency tuning, which also enables the phase and frequency of the parametric coupling to be varied, and we show that the resulting phase and frequency dependence of the amplification follow the theory of parametric resonance. We expect that this phenomenon will be useful for both fundamental studies of dynamic systems with low dissipation and for increasing signal-to-noise ratio in practical applications such as gyroscopes.
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http://dx.doi.org/10.1038/srep09036 | DOI Listing |
Ital J Pediatr
January 2025
Pediatrics Department, Genetics Unit, Mansoura University, Mansoura, Egypt.
Background: Pompe disease is a rare genetic disorder caused by a deficiency of the enzyme acid alpha-glucosidase. This condition leads to muscle weakness, respiratory problems, and heart abnormalities in affected individuals.
Methods: The aim of the study is to share our experience through cross sectional study of patients with infantile-onset Pompe disease (IOPD) with different genetic variations, resulting in diverse clinical presentations.
Sci Rep
January 2025
Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, South China Normal University, Guangzhou, 510631, People's Republic of China.
Prominent platforms based on thin-film lithium niobate (TFLN) are superior integrated-photonics platforms for efficient optical parametric amplification (OPA), however, previously few studies have been systematically reported the gain-boosting performance of TFLN waveguides compared to bulk LN waveguides. Here, we optimize two TFLN waveguides with dispersion engineering for high-efficiency and ultra-broadband gain of OPA, then report comparative results about the efficient ultra-broadband OPA of TFLN waveguides in the case of low loss, optimized waveguide length and pump power. Note that the efficient ultra-broadband OPA of TFLN waveguides is represented by the peak gain (71.
View Article and Find Full Text PDFNat Commun
January 2025
CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, CAS Center for Excellence in Complex System Mechanics, University of Science and Technology of China, Hefei, Anhui, China.
Control of crack propagation is crucial to make tougher heterogeneous materials. As a crack interacts with material heterogeneities, its front distorts and adopts complex tortuous configurations. While the behavior of smooth cracks with straight fronts in homogeneous materials is well understood, the toughening by rough cracks with tortuous fronts in heterogeneous materials remains unsolved.
View Article and Find Full Text PDFJ Acoust Soc Am
December 2024
Department of Mechanical Engineering, Rowan University, Glassboro, New Jersey 08028, USA.
Space-time modulation opens the door for unprecedented wave behavior control, such as nonreciprocal wave manipulation. Here is proposed a one-dimensional space-time modulated membrane system aiming to realize a kind of acoustic metamaterial with space-time modulated effective density. Three different approaches, namely, the effective medium method, transfer matrix method, and time-domain simulation, are applied to analyze the acoustic response of the system under a monochromatic incidence.
View Article and Find Full Text PDFJ Oral Pathol Med
January 2025
Human and Medical Genetics Laboratory, Federal University of Jataí, Jataí, Goiás, Brazil.
Background: Lip exposure to carcinogens lead to several disorders, such as actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC). Although several studies have described important pathways in lip carcinogenesis, the comprehension of association of target genes in this process and their association with tumor microenvironment still need to be better understood.
Methods: Tissue samples of 30 AC and 17 LLSCC cases were included for histopathological analysis, immunohistochemical expression of CD4, CD8, and PD-L1, and fluorescence in situ hybridization for AURKA, AURKB, TP53, PTEN, CCND1, and MYC.
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