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Clinical and preclinical evidence of psilocybin as antidepressant. A narrative review.
Prog Neuropsychopharmacol Biol Psychiatry
January 2025
Department of Pharmacology, University of the Basque Country UPV/EHU, Leioa, Bizkaia, Spain; Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Spain; Biobizkaia Health Research Institute, Barakaldo, Bizkaia, Spain. Electronic address:
In the rapidly growing field of psychedelic research, psilocybin (and active metabolite psilocin) has been proposed as a promising candidate in the search for novel treatments for neuropsychiatric disorders. Clinical trials have revealed that psilocybin has a large, rapid, and persistent effect in the improvement of symptoms of depression and anxiety. The safety profile is considered favourable, with low toxicity and good tolerance.
View Article and Find Full Text PDFComparison of treatments for equine laryngeal hemiplegia using computational fluid dynamic analysis in an equine head model.
Front Vet Sci
December 2024
Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Introduction: Computational fluid dynamics (CFD) is gaining momentum as a useful mechanism for analyzing obstructive disorders and surgeries in humans and warrants further development for application in equine surgery. While advancements in procedures continue, much remains unknown about the specific impact that different surgeries have on obstructive airway disorders. The objective of this study was to apply CFD analysis to an equine head inhalation model replicating recurrent laryngeal neuropathy (RLN) and four surgical procedures.
View Article and Find Full Text PDFPractices and preferences in the use of magnification among endodontists and restorative dentists: A multicentre study.
PLoS One
January 2025
Department of Prosthetic Dental Sciences, Jouf University, Sakaka, KSA Kingdom of Saudi Arabia.
Background And Objectives: Aim of the current study was to assess the perception, preference, and practice of endodontists and restorative dentists at different locations around the world about dental magnification instruments.
Materials And Methods: A multicenter, cross-sectional study was ethically approved from the local committee of bioethics. After thorough literature search, a questionnaire was designed and validated.
DFAST_QC: quality assessment and taxonomic identification tool for prokaryotic Genomes.
BMC Bioinformatics
January 2025
Department of Genetics, School of Life Science, The Graduate University for Advanced Studies (SOKENDAI), Mishima, 411-8540, Japan.
Background: Accurate taxonomic classification in genome databases is essential for reliable biological research and effective data sharing. Mislabeling or inaccuracies in genome annotations can lead to incorrect scientific conclusions and hinder the reproducibility of research findings. Despite advances in genome analysis techniques, challenges persist in ensuring precise and reliable taxonomic assignments.
View Article and Find Full Text PDFChild-Centric Robot Dialogue Systems: Fine-Tuning Large Language Models for Better Utterance Understanding and Interaction.
Sensors (Basel)
December 2024
Department of Information Convergence Engineering, Pusan National University, Busan 46241, Republic of Korea.
Dialogue systems must understand children's utterance intentions by considering their unique linguistic characteristics, such as syntactic incompleteness, pronunciation inaccuracies, and creative expressions, to enable natural conversational engagement in child-robot interactions. Even state-of-the-art large language models (LLMs) for language understanding and contextual awareness cannot comprehend children's intent as accurately as humans because of their distinctive features. An LLM-based dialogue system should acquire the manner by which humans understand children's speech to enhance its intention reasoning performance in verbal interactions with children.
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