Objective: The aim of this study was to investigate the prevalence of colorectal neoplasms in patients coronary artery disease (CAD) with or without a family history of colorectal cancer (CRC).
Methods: In this cross-sectional study, individuals with suspected CAD in the absence of cancer-related symptoms underwent coronary angiography for the first time, and were divided into CAD and non-CAD groups. Colonoscopy was performed in individuals at high-risk tier based on their Asia-Pacific colorectal screening (APCS) score. Their waist circumference (WC), height and body weight were measured.
Results: There were 634 of 1157 individuals at a high risk of developing advanced colorectal neoplasms, 91.0% (577/634) of whom were male smokers. The proportion of CAD patients in the high-risk tier was 81.5% (517/634), while the prevalences of adenomas (32.1% vs 22.2%, P < 0.05) and advanced adenomas (14.7% vs 8.5%, P < 0.05) were significantly higher in the CAD group than in the non-CAD group. After 83 individuals with a family history of CRC were excluded, only the prevalence of adenomas was still significantly higher in the CAD group than in the non-CAD group (25.5% vs 16.0%, P < 0.01). Body mass index (BMI) ≥ 25 kg/m(2) was correlated with the occurrence of adenomas (OR 2.133, 95% CI 1.219-3.730, P = 0.008) in CAD patients.
Conclusions: Even in the absence of family history of CRC, CAD patients at a high risk of developing advanced colorectal neoplasms classified by the APCS score still showed a remarkably high prevalence of colorectal adenomas. Moreover, the association between the occurrence of adenomas and CAD was stronger in overweight (BMI ≥ 25 kg/m(2)) individuals.
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