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Clinician's Guide to Epitranscriptomics: An Example of N-Methyladenosine (mA) RNA Modification and Cancer.
Life (Basel)
September 2024
Laboratory for Hereditary Cancer, Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia.
Epitranscriptomics is the study of modifications of RNA molecules by small molecular residues, such as the methyl (-CH) group. These modifications are inheritable and reversible. A specific group of enzymes called "writers" introduces the change to the RNA; "erasers" delete it, while "readers" stimulate a downstream effect.
View Article and Find Full Text PDFEnhanced PROcedural Information READability for Patient-Centered Care in Interventional Radiology With Large Language Models (PRO-READ IR).
J Am Coll Radiol
January 2025
Harvard Medical School, Boston, Massachusetts; Massachusetts General Hospital, Boston, Massachusetts; IR Division Quality Director and Co-Director of IR Research and also Director of Precision Interventional and Medical Imaging Lab at the Division of Vascular and Interventional Radiology, Massachusetts General Hospital.
Article Synopsis
- The study evaluated how well GPT-4 could create understandable patient education materials for common interventional radiology procedures.
- A total of 10 procedures were assessed, with input from both clinical physicians and nonclinical assessors to measure clarity, appropriateness, and readability.
- Results indicated GPT-4 generated instructions that were generally appropriate and easier to read than existing patient resources, showing better accessibility for patients in terms of language complexity.
Public attitudes towards personal health data sharing in long-term epidemiological research: a Citizen Science approach in the KORA study.
BMC Public Health
August 2024
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Munich, Germany.
Background: Loss to follow-up in long-term epidemiological studies is well-known and often substantial. Consequently, there is a risk of bias to the results. The motivation to take part in an epidemiological study can change over time, but the ways to minimize loss to follow-up are not well studied.
View Article and Find Full Text PDFCorrection for partial volume averaging in the quantification of radiopaque nanomaterial-embedded resorbable polymers.
Biomed Phys Eng Express
August 2024
The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, 77030, United States of America.
Resorbable inferior vena cava (IVC) filters require embedded contrast for image-guided placement and integrity monitoring. We calculated correction factors to account for partial volume averaging of thin nanoparticle (NP)-embedded materials, accounting for object and slice thicknesses, background signal, and nanoparticle concentration. We used phantoms containing polycaprolactone disks embedded with bismuth (Bi) or ytterbium (Yb): 0.
View Article and Find Full Text PDFAssessment of the impact of dams on aquatic food webs using stable isotopes: Current progress and future challenges.
Sci Total Environ
December 2023
Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds, School of Ecology, Environment and Resources, Guangdong University of Technology, Guangzhou 510006, China.
Dams have disrupted natural river systems worldwide and although population and community level effects on aquatic biota have been well documented, food web responses remain poorly understood and difficult to characterize. The application of stable isotope analysis (SIA) provides a means to assess the effect of dams on food webs. Here we review the effect of dams on aquatic food webs using SIA, aiming to detect knowledge gaps in the field of dam impacts on aquatic food webs and propose a conceptual framework to help formulate hypotheses about dam impacts on food webs guided by food web theory.
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