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24 January 2025: This paper was inadvertently published prematurely before all proof corrections had been finalized. It has been temporarily unpublished while this is rectified.
View Article and Find Full Text PDFMitoMAMMAL: a genome scale model of mammalian mitochondria predicts cardiac and BAT metabolism.
Bioinform Adv
November 2024
Aix-Marseille University, CNRS, IBDM UMR7288, Turing Center for Living Systems (CENTURI), Marseille 13009, France.
Motivation: Mitochondria are essential for cellular metabolism and are inherently flexible to allow correct function in a wide range of tissues. Consequently, dysregulated mitochondrial metabolism affects different tissues in different ways leading to challenges in understanding the pathology of mitochondrial diseases. System-level metabolic modelling is useful in studying tissue-specific mitochondrial metabolism, yet despite the mouse being a common model organism in research, no mouse specific mitochondrial metabolic model is currently available.
View Article and Find Full Text PDFMetabolic Profiles of Encapsulated Chondrocytes Exposed to Short-Term Simulated Microgravity.
Ann Biomed Eng
December 2024
Department of Mechanical and Industrial Engineering, Montana State University, PO Box 173800, Bozeman, MT, 59717-3800, USA.
The mechanism by which chondrocytes respond to reduced mechanical loading environments and the subsequent risk of developing osteoarthritis remains unclear. This is of particular concern for astronauts. In space the reduced joint loading forces during prolonged microgravity (10 g) exposure could lead to osteoarthritis (OA), compromising quality of life post-spaceflight.
View Article and Find Full Text PDFCorrigendum: Digital assessments for children and adolescents with ADHD: a scoping review.
Front Digit Health
November 2024
Department of Psychiatry and Neuroscience, University of California, Riverside, CA, United States.
[This corrects the article DOI: 10.3389/fdgth.2024.
View Article and Find Full Text PDFA four-hit mechanism is sufficient for meningioma development.
J Neurooncol
February 2025
Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Purpose: Meningiomas are central nervous system tumors whose incidence increases with age. Benign meningioma pathogenesis involves germline or somatic mutation of target genes, such as NF2, leading to clonal expansion. We used an established cancer epidemiology model to investigate the number of rate-limiting steps sufficient for benign meningioma development.
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