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T50 Calciprotein Crystallization and the Decreased Role of Fetuin-A in Type 2 Diabetes.
J Atheroscler Thromb
December 2024
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka Metropolitan University Graduate School of Medicine.
Aim: Patients with type 2 diabetes mellitus (T2D) are prone to develop vascular calcification. Fetuin-A protects against vascular calcification but it increases insulin resistance. T50 calciprotein crystallization (also called serum calcification propensity) is a novel marker of calcification stress.
View Article and Find Full Text PDFBMP-4 and fetuin A in systemic sclerosis patients with or without calcinosis.
Front Immunol
December 2024
Dipartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Introduction: Systemic sclerosis (SSc) is a connective tissue disease at the interface between inflammation and autoimmunity progressively leading to diffuse microvascular and fibrotic involvement of the skin and of multiple internal organs. Approximately, 20-40% of SSc patients suffer from cutaneous calcinosis, a debilitating manifestation due to calcium salt deposition in soft connective tissues, causing pain, ulceration, infection, and deformities, responsible of severe functional limitations. Pathomechanisms are poorly understood as well as markers/molecules capable to predict the risk of patients to develop calcinosis.
View Article and Find Full Text PDFSerum sestrin 2 and fetuin-A are associated with early pleural involvement in patients with pulmonary tuberculosis: a cross-sectional study.
J Thorac Dis
November 2024
Department of Orthopedics, Hunan Chest Hospital, Changsha, China.
Background: Tuberculous pleuritis is the second most common extrapulmonary tuberculosis. Its prompt diagnosis and appropriate management are essential to decrease the morbidity and mortality of affected patients. We aimed to assess whether the serum sestrin 2 and fetuin-A levels can be used to diagnose early pleural involvement in patients with pulmonary tuberculosis.
View Article and Find Full Text PDFFetuin-A as a plausible biomarker for cardiac valve calcification in rheumatic heart disease patients from North India.
Asian Cardiovasc Thorac Ann
December 2024
Amity Institute of Virology and Immunology, Amity University Uttar Pradesh, Noida, Uttar Pradesh, India.
Background: Rheumatic heart disease (RHD) remains a persistent public health challenge, particularly prevalent in developing and underdeveloped regions despite concerted global eradication efforts. The progressive stage of RHD, marked by valvular calcification, necessitates the imperative need to identify prognostic biomarkers. Fetuin-A, well-known for its role as a negative inhibitor of ectopic calcification, is investigated in our study as a potential biomarker for cardiac valve calcification in RHD patients.
View Article and Find Full Text PDFCirculating adipokines and MRI markers of brain aging in middle-aged adults from the community.
J Alzheimers Dis
November 2024
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA.
Article Synopsis
- Midlife obesity may increase the risk of late-onset dementia, and studying adipokines (substances secreted by fat cells) could help understand this link in aging brains.
- Researchers analyzed serum concentrations of specific adipokines and their relationships to brain MRI markers in 1,882 middle-aged adults from the Framingham Heart Study.
- The study found that higher levels of certain adipokines, particularly RBP4, were associated with brain atrophy, including reduced brain volumes and increased ventricular sizes, suggesting that these factors could play a role in cognitive decline during midlife.
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