Objective: To characterize parasomnia behaviors on arousal from NREM sleep in Parkinson's Disease (PD) and Multiple System Atrophy (MSA).
Methods: From 30 patients with PD, Dementia with Lewy Bodies/Dementia associated with PD, or MSA undergoing nocturnal video-polysomnography for presumed dream enactment behavior, we were able to select 2 PD and 2 MSA patients featuring NREM Parasomnia Behviors (NPBs). We identified episodes during which the subjects seemed to enact dreams or presumed dream-like mentation (NPB arousals) versus episodes with physiological movements (no-NPB arousals). A time-frequency analysis (Morlet Wavelet Transform) of the scalp EEG signals around each NPB and no- NPB arousal onset was performed, and the amplitudes of the spectral frequencies were compared between NPB and no-NPB arousals.
Results: 19 NPBs were identified, 12 of which consisting of 'elementary' NPBs while 7 resembling confusional arousals. With quantitative EEG analysis, we found an amplitude reduction in the 5-6 Hz band 40 seconds before NPBs arousal as compared to no-NPB arousals at F4 and C4 derivations (p<0.01).
Conclusions: Many PD and MSA patients feature various NREM sleep-related behaviors, with clinical and electrophysiological differences and similarities with arousal parasomnias in the general population.
Significance: This study help bring to attention an overlooked phenomenon in neurodegenerative diseases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355286 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120973 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Psychopathology and NREM sleep parasomnias: A systematic review.
Sleep Med Rev
December 2024
Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland; Neurocenter of Southern Switzerland, Ente Ospedaliero Cantonale, Ospedale Civico, Lugano, Switzerland; University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. Electronic address:
Non-rapid eye movement (NREM) sleep parasomnias are abnormal motor and/or emotional behaviors originating from "deep" slow-wave sleep and with a multifactorial origin. The relationship between NREM parasomnias and psychopathology has been a topic of ongoing debate, but a comprehensive and systematic perspective has been lacking. This systematic review, conducted according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA-P) guidelines, aims to fill this gap in the literature.
View Article and Find Full Text PDFSpectral Dynamics Prior to Motor Events Differ Between NREM Sleep Parasomnias and Healthy Sleepers.
Sleep
October 2024
Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
Article Synopsis
- The study investigates "Disorders of Arousal" (DoA), such as sleepwalking, by comparing brain activity during DoA episodes with motor arousal in both DoA patients and healthy sleepers.
- Researchers used EEG recordings from 53 DoA patients and 33 control subjects to analyze EEG patterns and identify differences in brain activity.
- Results indicated that DoA episodes were characterized by distinct EEG patterns, suggesting alterations in the arousal process which will aid in future research into DoA's underlying causes and indicators.
Treating narcolepsy-related nightmares with cognitive behavioural therapy and targeted lucidity reactivation: A pilot study.
J Sleep Res
October 2024
Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Nightmares are a common symptom in narcolepsy that has not been targeted in prior clinical trials. This study investigated the efficacy of Cognitive Behavioural Therapy for Nightmares (CBT-N), adapted for narcolepsy, in a small group of adults. Given the high prevalence of lucid dreaming in narcolepsy, we added a promising adjuvant component, targeted lucidity reactivation (TLR), a procedure designed to enhance lucid dreaming and dream control.
View Article and Find Full Text PDFConscious experiences during non-rapid eye movement sleep parasomnias.
Neurosci Biobehav Rev
December 2024
Minnesota Regional Sleep Disorders Center, Departments of Psychiatry, Hennepin County Medical Center, USA; University of Minnesota Medical School, Minneapolis, MN, USA.
Disorders of Arousal (DOA) are non-rapid eye movement (NREM) parasomnias traditionally regarded as unconscious states. However, recent research challenges this assumption. This narrative review aims to explore the presence and qualitative features of conscious experiences in patients with DOA during their episodes.
View Article and Find Full Text PDFAssociation between sleep bruxism and snoring in adults: An observational study.
Sleep Med
December 2024
Brazilian Centre for Evidence Based Research, Brazil; Federal University of Santa Catarina, Florianópolis, Brazil.
Objective: This study evaluated the association between sleep bruxism and snoring. Additionally, the associations between sleep bruxism and age, sex, body mass index, sleep structure, sleep quality, and sleepiness were evaluated.
Methods: Adults suspected of having sleep disorders (n = 61) underwent single-night video polysomnography according to the American Academy of Sleep Medicine criteria.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!