Planning of pregnancy and management of chronic hepatitis B virus during pregnancy includes recognition of maternal virological status, assessment of liver disease severity and minimization of risk for mother to infant transmission of infection. Decisions regarding the use of antivirals during pregnancy need to be individualized. Monitoring for infection and immunization in newborns is also important. For mothers on antiviral therapy, breastfeeding is not recommended.
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http://dx.doi.org/10.1016/j.jceh.2012.09.001 | DOI Listing |
Chronic ingestion of foods containing elevated levels of beta carotene, a common dietary staple endemic in West Africa, may promote the development of yellow to orange hyperpigmentation of the oral mucosa and skin. This benign condition, known as carotenemia or hypercarotenemia, has received little attention in the general dental literature. The aim of this case report is to increase awareness of this phenomenon by describing the clinical presentation of a patient from Nigeria with conspicuous yellow discoloration of the floor of the mouth and soft palatal mucosa.
View Article and Find Full Text PDFFront Immunol
March 2025
Center of Liver Diseases Division 3, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Objective: To investigate virological response and predictive factors for antiviral treatment in chronic HBV patients with low ALT and high HBV DNA.
Methods: A retrospective study grouped chronic HBV patients by baseline ALT: ALT > 80 U/L (significantly elevated group, SAG), 40-80 U/L (mildly elevated group, MAG), and ≤ 40 U/L (normal group, NG). Inverse probability treatment weighting balanced confounding factors.
J Clin Transl Hepatol
March 2025
Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, Shaanxi, China.
Background And Aims: Chronic hepatitis B (CHB) remains a significant global health challenge, and effective antiviral therapies are essential for long-term management. This study aimed to evaluate the real-world effectiveness and safety of tenofovir amibufenamide (TMF) in a cohort of patients with chronic hepatitis B (CHB).
Methods: In this multicenter, prospective, real-world cohort study, 194 CHB patients were recruited from four hospitals between August 2021 and August 2022.
Int J Mol Sci
February 2025
Internal Diseases Unit, Department of Emergency Medicine, University Hospital "Sveti Georgi", 4000 Plovdiv, Bulgaria.
Membranous nephropathy (MN) is a disease with an etiology and pathogenesis that are still not fully understood, and it represents a great challenge. It is characterized by a variable course, spontaneous remissions and relapses. The inability to rely entirely on antibodies and the continuous threat of a malignant disease make the differentiation of MN types extremely difficult.
View Article and Find Full Text PDFInt J Mol Sci
February 2025
Department of Gastroenterology, Clinical and Hospital Center "Dr Dragisa Misovic-Dedinje", Heroja Milana Tepica 1, 11020 Belgrade, Serbia.
Autoimmune liver diseases involve a heterogeneous group of chronic inflammatory disorders, including autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis. Sometimes presented consistently as an overlapping syndrome, their pathogenesis is rather complex and has yet to be fully elucidated, despite extensive research efforts. This review article corroborates the molecular mechanisms of autoimmune liver diseases, as well as existing and potential therapeutic modalities.
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