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The PI3K pathway balances self-renewal and differentiation of nephron progenitor cells through β-catenin signaling. | LitMetric

The PI3K pathway balances self-renewal and differentiation of nephron progenitor cells through β-catenin signaling.

Stem Cell Reports

The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian EH25 9RG, UK; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK. Electronic address:

Published: April 2015

AI Article Synopsis

Article Abstract

Nephron progenitor cells differentiate to form nephrons during embryonic kidney development. In contrast, self-renewal maintains progenitor numbers and premature depletion leads to impaired kidney function. Here we analyze the PI3K pathway as a point of convergence for the multiple pathways that are known to control self-renewal in the kidney. We demonstrate that a reduction in PI3K signaling triggers premature differentiation of the progenitors and activates a differentiation program that precedes the mesenchymal-to-epithelial transition through ectopic activation of the β-catenin pathway. Therefore, the combined output of PI3K and other pathways fine-tunes the balance between self-renewal and differentiation in nephron progenitors.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400645PMC
http://dx.doi.org/10.1016/j.stemcr.2015.01.021DOI Listing

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