AI Article Synopsis
- Diarrhea is a major health issue for children in China, but limited data exists on its causes; this study aims to identify key pathogens responsible for childhood diarrhea.
- Data was collected from 213 hospitals over four years, analyzing stool samples from children to find pathogens like viruses, bacteria, and protozoa responsible for diarrhea.
- Results revealed that 44.6% of the samples tested positive for pathogens, with rotavirus and norovirus being the most prevalent, highlighting the need for targeted public health interventions in China.
Article Abstract
Objectives: Diarrhea is a leading cause of morbidity and mortality for children, although sparse data is available on the etiology of diarrhea in China. This study was conducted to determine main causes that underlie childhood diarrhea and related diseases.
Method: Surveillance data for diarrhea was collected from 213 participating hospitals between 2009 and 2013. These stool specimens, from children aged 0-59 months, were then analyzed for a panel of etiological agents consisting of 5 viruses, 8 bacteria and 3 protozoa. The proportion of children who tested positive for each pathogen was calculated and seasonal patterns for major organisms were determined.
Results: Pathogens were identified in 44.6% of the 32,189 samples from children with diarrhea. The most commonly detected pathogens were rotavirus (29.7% of cases), norovirus (11.8%), Diarrheagenic Escherichia coli (DEC; 5.0%), adenovirus (4.8%), non-typhoidal Salmonella (NTS; 4.3%), and Shigella spp. (3.6%). A strong seasonal pattern was observed for these organisms, including rotavirus (winter), norovirus (autumn), and DEC, NTS, and Shigella (summer).
Conclusion: A wide range of enteropathogens were detected in this five-year surveillance study; rotavirus and norovirus were most common among children under the age five. These findings should serve as robust evidence for public health entities when planning and developing national intervention programs in China.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667737 | PMC |
| http://dx.doi.org/10.1016/j.jinf.2015.03.001 | DOI Listing |
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