An 85-year-old man presented with an ulcerated pruritic nodule on the scalp. Histology of a deep curette specimen showed the typical features of a squamoid eccrine ductal carcinoma: superficial squamous differentiation and deep ductal structures.
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Squamoid Eccrine Ductal Carcinoma: An Unusual Diagnosis in a Pregnant Patient.
Cureus
October 2024
Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, USA.
Squamoid eccrine ductal carcinoma (SEDC) is an unusually rare neoplasm of the skin with a relatively high risk for local recurrence and a potential for metastasis. While typical presentations occur in older, male patients, this case report describes the diagnosis made in a pregnant patient in her third trimester. The clinical presentation, pathology, and treatment course of SEDC are outlined in this article.
View Article and Find Full Text PDFSquamoid Eccrine Ductal Carcinoma Displays Ultraviolet Mutations and Intermediate Gene Expression Relative to Squamous Cell Carcinoma, Microcystic Adnexal Carcinoma, and Porocarcinoma.
Mod Pathol
November 2024
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan; Rogel Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan.
Article Synopsis
- Squamoid eccrine ductal carcinoma is a rare tumor with characteristics that fall between squamous cell carcinoma (SCC) and certain sweat gland carcinomas, leading to debates on its classification.
- The study examined 15 cases of this carcinoma, revealing that most cases had UV signature mutations and TP53 mutations as the most common genetic alterations.
- Transcriptome analysis indicated that this carcinoma expresses 364 genes more and 525 genes less compared to SCC and sweat gland tumors, reinforcing the idea that it has an intermediate phenotype between these cancer types.
Squamoid eccrine ductal carcinoma: series of five cases of a rare tumor.
An Bras Dermatol
August 2024
Department of Dermatology, Faculty of Medicine, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brazil.
Squamoid eccrine ductal carcinoma: clinical, histological and immunohistochemical features.
Dermatol Online J
April 2024
Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Squamoid eccrine ductal carcinoma (SEDC) is a cutaneous adnexal malignancy that is histologically challenging to distinguish from squamous cell carcinoma. We report three cases of this rare entity and review the present literature regarding clinical, histological, and immunohistochemical features. Patients presented with a single nodule or plaque lesion on their back and temple.
View Article and Find Full Text PDFMohs surgery for squamoid eccrine ductal carcinoma.
J Cutan Aesthet Surg
January 2024
Central Clinical School, University of Sydney, The Skin Hospital, Darlinghurst, New South Wales, Australia.
Squamous eccrine ductal carcinoma is a rare cutaneous malignancy. It has the potential to locally recur and may occasionally metastasize. It presents a diagnostic challenge given its rare nature and overlapping histopathological features with other cutaneous carcinomas.
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