AI Article Synopsis

  • The study aimed to determine if exposure to polycyclic aromatic hydrocarbons (PAHs) in the environment is linked to sperm aneuploidy (abnormal number of chromosomes in sperm).
  • It involved 181 men from an infertility clinic, all of whom had normal to slightly low sperm concentrations.
  • The cross-sectional design allows for the analysis of data at a single point in time to assess potential associations between PAH exposure and reproductive health.

Article Abstract

The purpose of this cross-sectional study was to investigate whether environmental exposure to polycyclic aromatic hydrocarbons (PAHs) was associated with sperm aneuploidy. A sample of 181 men who attended an infertility clinic for diagnostic purposes and who had a normal semen concentration of 20-300×106 spermatozoa mL-1 or slight oligozoospermia (semen concentration of 15-20×106 spermatozoa mL-1;

Download full-text PDF

Source
http://dx.doi.org/10.1071/RD14063DOI Listing

Publication Analysis

Top Keywords

sperm aneuploidy
8
exposure polycyclic
8
polycyclic aromatic
8
aromatic hydrocarbons
8
semen concentration
8
spermatozoa ml-1
8
human sperm
4
aneuploidy exposure
4
hydrocarbons purpose
4
purpose cross-sectional
4

Similar Publications

The intricate "ART" of ICSI.

J Assist Reprod Genet

December 2024

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, 1305 York Avenue, Y720, New York, NY, 10021, USA.

This manuscript explores the intricacies and nuances of the Intracytoplasmic Sperm Injection (ICSI) procedure, drawing on insights from three decades of experience at a specialized center managing numerous cases of male factor infertility. Our center is comprised of an embryology laboratory, an andrology and assisted fertilization laboratory, and a Preimplantation Genetic Testing for Aneuploidy (PGT-A) laboratory, each fostering specialized expertise independently. Collaboration among these laboratories, alongside reproductive physicians and urologists, ensures comprehensive feedback and optimal care for patients undergoing infertility treatment.

View Article and Find Full Text PDF

Preimplantation development analysis of aneuploid embryos with different chromosomal abnormalities.

Heliyon

December 2024

Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Background: The change of morphokinetic pattern in aneuploid embryos will facilitate the non-invasive selection of euploid embryos. In this study, we investigated the impact of different chromosomal abnormalities on the morphokinetic patterns of embryonic development.

Methods: Our cohort includes 939 time-lapse preimplantation genetic testing cycles performed between January 2019 and July 2022 at a single academic fertility center, with a total of 2876 biopsied blastocysts.

View Article and Find Full Text PDF

A blastocyst's implantation potential is linked to its originating oocyte cohort's blastulation rate: evidence for a cohort effect.

Fertil Steril

December 2024

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, California.

Objective: To investigate if blastocysts originating from different follicular cohorts have variable implantation rates, adjusted for oocyte age, morphology and/or ploidy DESIGN: Retrospective cohort SETTING: Academic center SUBJECTS: Patients who underwent one or more cycles of autologous ovarian stimulation and in vitro fertilization/intracytoplasmic sperm injection, followed by elective single frozen blastocyst transfer EXPOSURE: Blastocyst progression rate of a follicular cohort; defined as the total number of expanded blastocyst, euploid blastocyst, Day 5 blastocyst, or Day 5 euploid blastocyst(s) divided by the number of 2 pronuclei (2PN) zygote(s) MAIN OUTCOME MEASURES: Implantation, defined as serum human chorionic gonadotropin >5mIU/ml following elective single embryo transfer (eSET) RESULTS: A total of 4,292 blastocysts were tracked from their follicular cohort origin to their outcome following eSET. The mean age±standard deviation of the study population was 36.2±3.

View Article and Find Full Text PDF

Using FRET to Define Cdk1-Dependent Ordering of Events During Exit from Second Meiotic M-Phase in Oocytes.

Methods Mol Biol

November 2024

Christopher Chen Oocyte Biology Research Laboratory, UQ Centre for Clinical Research, Herston, QLD, Australia.

Exit from M-phase requires a precise sequence of molecular events for successful completion, with errors in the process resulting in cell death or aneuploidy, a characteristic feature of cancer and the leading cause of pregnancy failure. Exit from the second meiotic division (MII) in oocytes is a unique event triggered by sperm, involving female anaphase II as well as both male and female pronuclear formation. Very little is known about how these events involving two distinct cell types are coordinated.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to explore how sperm quality (based on WHO-2021 criteria) and paternal factors like BMI and age relate to outcomes in ICSI cycles with PGT-A, focusing on clinical and embryological results.
  • Conducted at a private IVF clinic, the research included data from 3101 couples over several years, employing techniques like trophectoderm biopsies and chromosome testing to evaluate the success of fertilization and embryo development.
  • Results showed that maternal age significantly affected embryo quality, while lower sperm motility and specific conditions like obstructive and non-obstructive azoospermia were linked to poorer outcomes, including live birth rates.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!